Myocardial function, oxygen consumption and efficiency assessment in the right ventricle of patients with idiophathic pulmonary hypertrophy using positron emission tomography.
- Conditions
- (idiopathic) pulmonary hypertension or chronically increased pressure in the lungvessels resulting in enlarged right ventricle muscle and deterioration100192801003868610037454
- Registration Number
- NL-OMON31568
- Lead Sponsor
- Vrije Universiteit Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Newly diagnosed idiopathic PH, NYHA functional classification II to IV, not yet started with PH-medication, age 18 yrs and older
Exclusion Criteria
Secundary PH, anemia (Hb <8.0), previously known coronary disease, atrial fibrillation, diabetes mellitus, known malignancy, pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>- Oxygen consumption measurements of hypertrophic/failing RV with 11C-acetate<br /><br>and 15O-O2<br /><br>- Cardiac efficiency of RV<br /><br>- Myocardial glucose uptake of RV<br /><br>- Myocardial perfusion reserve of RV (see also Study Objectives no. 1 to 4) </p><br>
- Secondary Outcome Measures
Name Time Method <p>Relation between the efficiency, glucose uptake and perfusion to the wall<br /><br>stress of the RV (p. 9, wall stress explained)<br /><br>Oxygen consumption and glucose uptake measurements in the intraventricular<br /><br>septum<br /><br>Test-retest of the oxygen gas tracer for measurement of myocardial oxygen<br /><br>consumption </p><br>