Measuring heart muscle oxygenation in chest pain syndromes
Not Applicable
- Conditions
- eft ventricular hypertrophyHibernating myocardiumLeft ventricular hypertrophyCardiovascular - Coronary heart disease
- Registration Number
- ACTRN12610000038099
- Lead Sponsor
- Southern Adelaide Health Service
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 65
Inclusion Criteria
1. History of hypertension, left ventricular hypertrophy, exertional chest pain and/or breathlessness, normal epicardial arteries
2. Known coronary artery disease, impaired regional left ventricular function awaiting percutaneous coronary intervention or coronary artery bypass grafting
Exclusion Criteria
Inability to give written informed consent, estimated Glomerular Filtration Rate(GFR)<60mls/min, extreme claustrophobia, implantable cardiac devices and other contra-indications to Magnetic Resonance Imaging(MRI) (i.e. metal in eyes), asthma or other reversible bronchospasm
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Patients with left ventricular hypertrophy presenting with chest pain and/or exertional breathlessness with normal epicardial arteries have direct impairments in myocardial tissue oxygenation. Perfusion reserve and blood-level dependent (BOLD) signal will be determined in the treatment group versus the control group. Assessed by cardiac magnetic resonance imaging and echocardiography.[Baseline];Hibernating myocardial segments will maintain myocardial oxygenation levels similar to remote normal myocardium both in rest and stress. Regional wall motion, perfusion and oxygenation will be assessed by cardiac magnetic resonance imaging and echocardiography in the hibernating group versus the control group[Baseline and 6 months post revascularisation]
- Secondary Outcome Measures
Name Time Method none[none]