Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.
试验速览
- 阶段
- 3 期
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- pregnancy
研究概览
简要总结
Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate.
Minor data is available regarding the influence on male sperm.
详细描述
Pomegranate contains a high concentration of vitamins ( C, B1, B2, B3, B5), potassium, Magnesium , Zinc and is a good source for polyphenols .Polyphenols molecules have been found to possess antioxidant properties and may effects the expression of different genes . Recent studies indicate that among foods that contain polyphenols, juice extracted from the pomegranate has the highest concentration of measurable polyphenols . Pomegranates have shown inhibitory effect on NF-κB and the MAP kinases JNK and ERK, which are critical steps in the cascade of events leading to inflammatory response. The NF- κB pathway is activated in response to bacterial infection and initiates the inflammatory cascade, which may explain the protective effect of Pomegranates on bacterial infections.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 60 Years(Adult)
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •TMC of less than 5 million spermatogonia in native sperm and morphology less than 4% by Kruger criteria.
排除标准
- •sensitivity to Pomegranate
研究组 & 干预措施
No Pills
Patients in this group will not receive Pomegranate pills.
Pomegranate pills
The reccruited patient will receive pomegranate pills every day for 12 weeks. The control group will not be exposed for the pills.
干预措施: Pomegranate pills (Dietary Supplement)
结局指标
主要结局
pregnancy
时间窗: 24 month
次要结局
- ROS (reactive oxidative stress )and Interleukins level in semen fluid(12 weeks)
