Microneedling With Regular Insulin Versus Microneedling Alone in Treatment of Atrophic Scars
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Sponsor
- Alexandria University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Change in Scar
Overview
Brief Summary
Recently, few studies have attempted to test the regenerative effects of human insulin application by microneedling on atrophic scars versus other topical preparations. However, the scars were limited etiologically to acne scars. In addition, a lack of inclusion of a control group instead of comparing topical preparations with insulin was also a limitation to these studies. A control group consisting of microneedling alone would have served as a better comparison in order to determine whether the effects of microneedling are augmented by topical protein-rich preparations.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 12 Years to 60 Years (Child, Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients aged 12 to 60 years
- •Atrophic scars (traumatic or surgical)
- •Completely healed scars
Exclusion Criteria
- •Patients with a tendency or history of hypertrophic or keloidal scars
- •Patients who received treatment for their scar in the past 3 months
- •Diabetic patients or those with a history of Dysglycemia
- •Pregnant, or lactating females
- •Patients with active infection at the site of scar
- •Patients currently receiving isotretinoin treatment or in the past month
Outcomes
Primary Outcomes
Change in Scar
Time Frame: 4 months
According the different scar assessment scores (e.g.POSAS score - The Patient and Observer Scar Assessment Scale score, range from 6 to 60, the higher the score the worse the scar, lowering in the score denotes improvement )
Secondary Outcomes
No secondary outcomes reported
Investigators
Dalia Ibrahim Halwag
Lecturer and Consultant of Dermatology, Venereology and Andrology, Faculty of Medicine
Alexandria University