Impact of Augmenting Exercise Intensity vs. Frequency

Not Applicable

• Conditions: Exercise Training
• Interventions: Behavioral: Frequency comparison; Behavioral: Intensity comparison

• Registration Number: NCT04295590
• Lead Sponsor: Brendon Gurd, PhD

Brief Summary

The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Both training periods will be 4 weeks long and skeletal muscle biopsies will be collected from both legs before and after each training period. All exercise sessions will be supervised, take place in the investigator's laboratory, and occur on stationary bikes.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-30
• Status Verified: 2020-03
• Study First Submitted: 2020-03-02
• Study First Submitted QC: 2020-03-03
• Last Update Submitted: 2020-03-03
• Study First Posted: 2020-03-04
• Last Update Posted: 2020-03-04
• Primary Completion: 2020-04-10
• Study Completion: 2020-04-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Recreational active (<3 hours per week of aerobic exercise)
• Willing to provide skeletal muscle biopsies

Exclusion Criteria

• Cardiovascular or metabolic disease
• Athletes or individuals exceeding 3 hours per week of aerobic exercise
• Smokers

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Frequency then Intensity	Frequency comparison	Training period 1: Frequency comparison Training period 2: Intensity comparison
Frequency then Intensity	Intensity comparison	Training period 1: Frequency comparison Training period 2: Intensity comparison
Intensity then Frequency	Frequency comparison	Training period 1: Intensity comparison Training period 2: Frequency comparison
Intensity then Frequency	Intensity comparison	Training period 1: Intensity comparison Training period 2: Frequency comparison

Primary Outcome Measures

Name	Time	Method
Peak work rate	Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)	Change in Highest work rate achieved (30s period) during incremental exercise tests

Secondary Outcome Measures

Name	Time	Method
Peak oxygen uptake	Before exercise training on two days (~7 and 6 days before first training session; ~24 hours apart), and after exercise on two days (~48-96 hours after the last training session; ~24 hours apart)	Change in Highest oxygen uptake achieved (30s period) during incremental exercise tests
Maximal citrate synthase activity	Before exercise training (~7 days before first training session), and after exercise training (~48-72 hours after the last training session)	Change in maximal citrate synthase activity

Trial Locations

Locations (1)

Queen's Muscle Physiology Lab in the School of Kinesiology and Health Studies at Queen's University; 🇨🇦 Kingston, Ontario, Canada