Effects of Different Intensities of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hypertension
- Sponsor
- Federal University of Paraíba
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- Systolic, diastolic and media blood pressure
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of this intervention study is to evaluate the acute and chronic effects of different intensity (mild, moderate and high intensity) of aerobic exercise on blood pressure levels of subjects classified as resistant hypertension. Resistant hypertensives subjects aged 40 to 70, men or women with body mass index lower that 40 kg/m² are recruited and subjected in acute phase in three sessions of aerobic exercise: mild, moderate, high intensity; and session control. After, the subjects will be randomly allocated into four intervention groups: mild intensity group, moderate intensity group, high intensity group and control group. In both phases, the subjects have blood pressure data recorded by ambulatory blood pressure monitoring, for clinic and ambulatory analysis. In addition, continuously be registered biological signs of blood pressure (finometer), electrocardiogram (DII derivation) and blood flow (venous occlusion plethysmography) for analysis of cardiac autonomic modulation, vascular autonomic modulation, baroreflex sensitivity, vasodilator response and peripheral vascular resistance.
Investigators
Leone Severino do Nascimento
Leone Severino do Nascimento, Universidade Federal da Paraíba
Federal University of Paraíba
Eligibility Criteria
Inclusion Criteria
- •Age between 40 and 70 years
- •Men or women
- •Body mass index under 40 kg / m²
- •Able to participate in exercise
- •No regular physically active in the last 4 months
Exclusion Criteria
- •Smoking; with history of ischemic stroke or hemorrhagic; or coronary heart disease; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation.
Outcomes
Primary Outcomes
Systolic, diastolic and media blood pressure
Time Frame: Pre and post-intervention (8 weeks)
Control in blood pressure levels, assess by the method of Ambulatory Blood Pressure Monitoring (ABPM), from decrease of blood pressure in measurements pre and post-intervention with physical exercise.
Secondary Outcomes
- Autonomic Modulation(Pre and post-intervention (8 weeks))
- Baroreflex Sensitivity(Pre and post-intervention (8 weeks))
- Vasodilator Response(Pre and post-intervention (8 weeks))