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Clinical Trials/NCT02188342
NCT02188342
Completed
Not Applicable

Effectiveness of Short Term, High Intensity, Interval Exercise Training in Older Colorectal Cancer Patients in Improving Preoperative Fitness

University of Nottingham1 site in 1 country18 target enrollmentJanuary 2015
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ConditionsPreoperative CareColorectal NeoplasmsAgedExercise

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Preoperative Care
Sponsor
University of Nottingham
Enrollment
18
Locations
1
Primary Endpoint
VO2 peak
Status
Completed
Last Updated
8 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

The primary aim of this study is to determine whether an improvement in aerobic fitness, as judged by an increase in VO2peak, can be achieved within 31 days via HIT programme in a group of older, colorectal cancer patients.

Detailed Description

12 high intensity interval training exercise sessions on a static cycle ergometer, over a period of 31 days. Each session lasts 18 minutes. At the beginning and end of the study the following measures will be used to assess change in fitness, body composition and muscle metabolism. DXA scan, USS of thigh, VO2 peak cycling test, short performance battery tests, quality of life questionnaires and muscle biopsy.

Registry
clinicaltrials.gov
Start Date
January 2015
End Date
April 2017
Last Updated
8 years ago
Study Type
Interventional
Study Design
Single Group
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Confirmed colorectal cancer
  • •Offered curative treatment by the Royal Derby Hospital NHS Foundation Trust Colorectal Cancer Multidisciplinary Team
  • •Male and female
  • •18-88 years of age

Exclusion Criteria

  • •Uncontrolled hypertension (BP \> 160/100),
  • •Heart failure (class III/IV),
  • •Cardiac arrthymias,
  • •Right to left cardiac shunt,
  • •Recent cardiac event,
  • •Previous stroke/TIA,
  • •Aneurysm (large vessel or intracranial),
  • •Severe respiratory disease including pulmonary hypertension,
  • •COPD/asthma with an FEV1 less than 1.5 l,
  • •Coagulation disorders,

Outcomes

Primary Outcomes

VO2 peak

Time Frame: After 31 days of HIT

Mean difference in VO2 peak following a HIT programme

Secondary Outcomes

  • Anaerobic threshold(After 31 days of HIT)
  • Muscle protein synthesis(After 31 days of HIT)
  • Feasibility(After 31 days of HIT)
  • Quality of life(After 31 days of HIT)
  • Body composition(After 31 days of HIT)

Study Sites (1)

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