Improvements in Aerobic Performance Following a Four-week Period of High Intensity Interval Training in the Elderly.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcopenia
- Sponsor
- University of Nottingham
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Mean anaerobic threshold improvement following 4 week HIT protocol.
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
This pilot study aims to investigate whether high intensity interval training can result in rapid improvements in physical fitness amongst the frail elderly (over 70 years old). Participants will undergo a wide range of physical fitness measures followed by a four week exercise protocol. Determination of improvement will be by repeated testing of the physical measures taken for baseline. The primary outcome measure will be anaerobic threshold. There will also be a subgroup of participants who will undergo muscle biopsy and D2O ingestion to allow an insight into the mechanistic basis behind exercise training response in this age group.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Aged over 70 years.
- •Sufficient mobility to be able to exercise on a static exercise bike.
- •Availability for the entire trial period.
- •Sufficient capacity to consent for the trial.
Exclusion Criteria
- •Participants under the age of 70 years.
- •Participants with a significant past medical history of:
- •Myocardial infarction (within last 6 months)
- •Unstable Angina
- •Heart failure (NYHA class III/IV)
- •Uncontrolled Hypertension (BP\>160/100)
- •Previous stroke/TIA
- •Severe respiratory disease inc. known pulmonary hypertension(\>25 mmHg), Forced -Expiratory Volume in 1 second \<1.5l.
- •Brittle asthma / exercise induced asthma
- •Known cerebral aneurysm or abdominal aortic aneurysm.
Outcomes
Primary Outcomes
Mean anaerobic threshold improvement following 4 week HIT protocol.
Time Frame: 4 weeks
Measured via cardiopulmonary exercise testing (mls/kg/min and absolute value L/kg). Pre-Post testing.
Secondary Outcomes
- Mean VO2 peak improvement following 4 week HIT protocol.(4 weeks)
- Muscle protein synthesis(4 weeks)
- Body composition(4 weeks)
- Muscle architecture(4 weeks)
- Feasibility(4 Weeks)
- Quality of life improvement(4 weeks)
- Daily Activity Level(4 weeks)
- Physical Activity Score(4 weeks)