NCT02459132CompletedNot Applicable
A Phase II Randomized Trial of High-Intensity Aerobic Interval Training and Surrogate Markers of Cardiovascular Disease in a Population-based Sample of Testicular Cancer Survivors
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Alberta
- Enrollment
- 63
- Primary Endpoint
- Peak aerobic capacity (relative VO2peak)
Study Overview
Brief Summary
This study evaluates the impact of a supervised 12-week high-intensity aerobic interval exercise program (versus a self-directed exercise usual care group) on traditional and novel cardiovascular disease risk factors and surrogate markers of cardiovascular- and overall-mortality in a population-based sample of testicular cancer survivors.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •histologically confirmed history of testicular cancer
Exclusion Criteria
- •Not sufficiently ambulatory to complete the first two stages of the aerobic exercise test.
- •Have a psychiatric condition which impairs their ability to perform the required volume and intensity of exercise.
- •Have any uncontrolled cardiovascular condition (i.e. heart disease, hypertension, diabetes, arrhythmia).
- •Report performing any weekly vigorous intensity aerobic exercise in the past month.
Outcomes
Primary Outcomes
Peak aerobic capacity (relative VO2peak)
Time Frame: Baseline and within 7 days of completing the 12-week intervention
ml O2/kg/min
Secondary Outcomes
- Peak aerobic capacity (absolute VO2peak)(Baseline and within 7 days of completing the 12-week intervention)
- Postexercise 1-minute heart rate recovery(Baseline and within 7 days of completing the 12-week intervention)
- Average carotid intima-media thickness(Baseline and within 7 days of completing the 12-week intervention)
- Carotid distensibility(Baseline and within 7 days of completing the 12-week intervention)
- Velocity time integral(Baseline and within 7 days of completing the 12-week intervention)
- Respiratory sinus arrhythmia(Baseline and within 7 days of completing the 12-week intervention)
- Diastolic blood pressure(Baseline and within 7 days of completing the 12-week intervention)
- Brachial diameter(Baseline and within 7 days of completing the 12-week intervention)
- Maximal carotid intima-media thickness(Baseline and within 7 days of completing the 12-week intervention)
- Carotid diameter(Baseline and within 7 days of completing the 12-week intervention)
- Brachial flow-mediated dilation(Baseline and within 7 days of completing the 12-week intervention)
- Heart rate(Baseline and within 7 days of completing the 12-week intervention)
- Systolic blood pressure(Baseline and within 7 days of completing the 12-week intervention)
- Femoral-toe pulse wave velocity(Baseline and within 7 days of completing the 12-week intervention)
- Low-density lipoprotein(Baseline and within 7 days of completing the 12-week intervention)
- Total cholesterol : high-density lipoprotein ratio(Baseline and within 7 days of completing the 12-week intervention)
- Vascular age(Baseline and within 7 days of completing the 12-week intervention)
- Carotid-femoral pulse wave velocity(Baseline and within 7 days of completing the 12-week intervention)
- Fibrinogen(Baseline and within 7 days of completing the 12-week intervention)
- Total cholesterol(Baseline and within 7 days of completing the 12-week intervention)
- Triglycerides(Baseline and within 7 days of completing the 12-week intervention)
- Shear stress during reactive hyperemia(Baseline and within 7 days of completing the 12-week intervention)
- High-density lipoprotein(Baseline and within 7 days of completing the 12-week intervention)
- Testosterone(Baseline and within 7 days of completing the 12-week intervention)
- Framingham Risk Score(Baseline and within 7 days of completing the 12-week intervention)
- High-sensitivity C-reactive protein(Baseline and within 7 days of completing the 12-week intervention)
- Fasting glucose(Baseline and within 7 days of completing the 12-week intervention)
- Modifiable CVD Risk Factor Score(Baseline and within 7 days of completing the 12-week intervention)
Investigators
Similar Trials
Completed
Not Applicable
HIT Training in the Frail Elderly.SarcopeniaAgedExercisePreoperative CareNCT03138265University of Nottingham32
Completed
Not Applicable
High Intensity Aerobic Interval Training Versus Continuous Training in Heart Failure Patients.Heart FailureNCT05948371Riphah International University26
Completed
Not Applicable
Intervention Study to Assess the Effects of Moderate and High Intensity Aerobic Training on Physical Capacity and Activity Level in Persons With Incomplete Spinal Cord InjurySpinal Cord InjuryNCT01903226Sunnaas Rehabilitation Hospital30
Completed
Not Applicable
The Effect of HIT in Patients With Non-alcoholic Fatty Liver Disease/SteatohepatitisNon-alcoholic Fatty Liver DiseaseNon-alcoholic SteatohepatitisNCT02528305University of Bath12
Completed
Not Applicable
The Impact of High-Intensity Interval Training Exercise on Breast Cancer Survivors: A Pilot Study to Explore Fitness, Cardiac Regulation and Biomarkers of the Stress SystemsCancer - BreastBreast CancerACTRN12620000684921niversity of Canberra17
