Effects of Different Intensities of Aerobic Exercise on Blood Pressure Levels of Resistant Hypertensive Subjects
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Systolic, diastolic and media blood pressure
研究概览
简要总结
The aim of this intervention study is to evaluate the acute and chronic effects of different intensity (mild, moderate and high intensity) of aerobic exercise on blood pressure levels of subjects classified as resistant hypertension. Resistant hypertensives subjects aged 40 to 70, men or women with body mass index lower that 40 kg/m² are recruited and subjected in acute phase in three sessions of aerobic exercise: mild, moderate, high intensity; and session control. After, the subjects will be randomly allocated into four intervention groups: mild intensity group, moderate intensity group, high intensity group and control group. In both phases, the subjects have blood pressure data recorded by ambulatory blood pressure monitoring, for clinic and ambulatory analysis. In addition, continuously be registered biological signs of blood pressure (finometer), electrocardiogram (DII derivation) and blood flow (venous occlusion plethysmography) for analysis of cardiac autonomic modulation, vascular autonomic modulation, baroreflex sensitivity, vasodilator response and peripheral vascular resistance.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 40 and 70 years
- •Men or women
- •Body mass index under 40 kg / m²
- •Able to participate in exercise
- •No regular physically active in the last 4 months
排除标准
- •Smoking; with history of ischemic stroke or hemorrhagic; or coronary heart disease; or obstructive pulmonary disease or chronic restrictive; or diabetes mellitus; or chronic atrial fibrillation.
研究组 & 干预措施
Aerobic Exercise Mild Intensity
The subjects engage in aerobic exercise training (8 weeks) of mild intensity (continuous). The intensity is controlled by a corresponding heart rate at anaerobic threshold.
干预措施: Aerobic Exercise Training (Behavioral)
Aerobic Exercise Moderate Intensity
The subjects engage in aerobic exercise training (8 weeks) of moderate intensity (continuous). The intensity is controlled by a corresponding heart rate between anaerobic threshold and respiratory compensation point.
干预措施: Aerobic Exercise Training (Behavioral)
Aerobic Exercise High Intensity
The subjects engage in aerobic exercise (8 weeks) of high intensity interval training. The intensity is controlled by a corresponding heart rate above respiratory compensation point.
干预措施: Aerobic Exercise Training (Behavioral)
结局指标
主要结局
Systolic, diastolic and media blood pressure
时间窗: Pre and post-intervention (8 weeks)
Control in blood pressure levels, assess by the method of Ambulatory Blood Pressure Monitoring (ABPM), from decrease of blood pressure in measurements pre and post-intervention with physical exercise.
次要结局
- Autonomic Modulation(Pre and post-intervention (8 weeks))
- Baroreflex Sensitivity(Pre and post-intervention (8 weeks))
- Vasodilator Response(Pre and post-intervention (8 weeks))
研究者
Leone Severino do Nascimento
Leone Severino do Nascimento, Universidade Federal da Paraíba
Federal University of Paraíba