Treatment of Central Sleep Apnea Syndrome with low-pressure nasal continuous positive airway pressure and rebreathing.
Withdrawn
- Conditions
- sleep apnea10040998
- Registration Number
- NL-OMON39400
- Lead Sponsor
- Medisch Centrum Alkmaar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 10
Inclusion Criteria
outpatients diagnosed with central sleep apnea syndrome by polysomnography with sleep apnea index *15 and at least 50% of all apneas is central in origin without obstructieve components.
Age 18-80 years
Patients are using or have been using CPAP.
Informed Consent
Exclusion Criteria
History of heart failure, cardiac arrhythmia or cardiac ischemia,
History of stroke
Cheyne Stokes breathing during daytime,
Sedatives or hypnotic agents, opioids.,
Respiratory failure( hypoxia, hypercapnia or respiratory acidosis during daytime)
Pulmonary diseases
Body mass index * 30
Untreated thyroid disease
pregnancy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary study parameters/endpoints<br /><br>Apnea Hypopnea Index with low-pressure nCPAP and added dead space versus<br /><br>low-pressure nCPAP only</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary study parameters/endpoints<br /><br>* Blood pressure measured during low-pressure nCPAP with added dead space and<br /><br>low-pressure nCPAP only.<br /><br>* Sleep structure during low-pressure nCPAP with added dead space and<br /><br>low-pressure nCPAP only.<br /><br>* Subjective quality of sleep during low-pressure nCPAP with added dead space<br /><br>and low-pressure nCPAP only.<br /><br>* Heartrate variability during low-pressure nCPAP with added dead space and<br /><br>low-pressure nCPAP only.</p><br>