Exercise CMR in (p)LF-LG AS

Recruiting

• Conditions: Aortic Stenosis, Severe

• Registration Number: NCT06129799
• Lead Sponsor: University of Göttingen

Brief Summary

Patient with paradoxical or conventional low-flow low-gradient aortic stenosis on echocardiographic assessment will undergo physiological exercise-stress CMR in addition to guideline recommended surveys prior to TAVR.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-11
• Study Start: 2023-11-01
• Study First Submitted: 2023-11-06
• Study First Submitted QC: 2023-11-09
• Last Update Submitted: 2023-11-09
• Study First Posted: 2023-11-13
• Last Update Posted: 2023-11-13
• Primary Completion: 2025-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• paradoxical or conventional severe low-flow low-gradient aortic stenosis

Exclusion Criteria

• CMR incapable device
• unable to undergo 40 min scan (can not lie flat, claustrophobia)
• renal insufficiency (eGFR <30 ml/min/1.73m²)
• allergy against contrast agent
• unable to exercise in supine position

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite of events: number of participants with cardiovascular death or heart failure hospitalisation	12 months

Trial Locations

Locations (1)

University Hospital Goettingen; 🇩🇪 Göttingen, Germany