CMR Exercise Stress Testing in HFpEF

Not Applicable

Completed

Brief Summary: Patients of the University Hospital Göttingen with echocardiographic signs for diastolic heart failure and indication for right heart catheterisation will undergo additional diagnostic testing with CMR including exercise stress for detailed evaluation of diastolic dysfunction and tissue characterisation correlating the results with well-established clinical standards.

Recruitment & Eligibility

Inclusion Criteria

adult patients with dyspnoea under stress, echocardiographic criteria for diastolic dysfunction (E/E'>8) and clinical indication for right heart catheterisation

Exclusion Criteria

arrhythmia (brady- or tachycardic)
bronchial asthma (allergic)
incompliant patient
pacemaker, ICD, non MRI-capable devices
inability to use the ergometer in the MRI
haemodynamic relevant valvular heart disease
pulmonary disease (vital capacity or forced expiratory flow <80% of healthy control)
angina pectoris
post cardiac infarction
anaemia (Hb <12 g/dl)
uncontrollable hypertension (>150 mmHg systolic or >100 mmHg diastolic)
age <18 years
pregnancy
claustrophobia
renal insufficiency
allergic to gadolinium based contrast agents

Arm && Interventions

Group	Intervention	Description
echocardiographic increase in left atrial pressure	stress CMR	-
echocardiographic no increase in left atrial pressure	stress CMR	-

Primary Outcome Measures

Name	Time	Method
Cardiovascular magnetic resonance imaging	approx. 1 years	quantification of extracellular volume (ECV)/interstitial fibrosis

Secondary Outcome Measures

Name	Time	Method

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