The University Hospital of South Manchester Cardiovascular Magnetic Resonance Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 10,000
- 试验地点
- 1
- 主要终点
- All cause mortality
研究概览
简要总结
This study aims to investigate the diagnostic and prognostic utility of cardiovascular magnetic resonance (CMR) imaging in a large cohort of unselected patients who are undergoing CMR scanning for clinical indications (i.e. suspected/confirmed cardiovascular disease). CMR indices will be related to the presence and severity of cardiovascular disease and other markers of cardiovascular and health status.
详细描述
Patients will undergo CMR scanning in the usual clinical manner. As part of the study, patients will undergo approximately 5 minutes of extra CMR scanning. Cardiovascular anatomical, structural and functional data will be recorded, including data pertaining to myocardial characteristics (e.g. extracellular volume, oedema, fibrosis, infarction, function, perfusion), pericardial disease; valvular disease; vascular structure and function.
Blood sampling will be performed on the same day as CMR scanning for assessment of serum/plasma markers of cardiovascular disease and health status, and DNA analysis. Health questionnaires will be completed on the day of CMR scanning.
Follow-up information regarding health status, demographics and concurrent medical conditions and treatments will be obtained over a 10 year period following CMR scanning.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Any adult patient undergoing clinically indicated CMR scanning at the UHSM CMR Unit.
排除标准
- •Age < 18 years, imprisonment, inability to provide informed consent.
结局指标
主要结局
All cause mortality
时间窗: 10 years with planned interim analyses
次要结局
- Cardiovascular death(10 years with planned interim analyses)
- Hospitalisation for heart failure(10 years with planned interim analyses)
- Development of cardiovascular disease(10 years with planned interim analyses)
- Development of complications of cardiovascular disease(10 years with planned interim analyses)