Detection and Prognostic Significance of Myocardial Damage Visualized by Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 27,000
- 试验地点
- 1
- 主要终点
- Pulmonary mortality
研究概览
简要总结
The primary objective of this study was to determine the ability of cardiac magnetic resonance (CMR) to identify cardiac involvement in patients with sarcoidosis. Patients were to undergo CMR in addition to routine clinical evaluation.
详细描述
In patients with sarcoidosis, cardiac death is a leading cause of mortality which may represent unrecognized cardiac involvement. Cardiovascular magnetic resonance (CMR) can detect cardiac involvement including minute amounts of myocardial damage. Therefore, the objective of this study was to determine the usefulness of CMR and compare it with standard clinical evaluation for cardiac involvement. Patients with documented extracardiac sarcoidosis or clinically suspected cardiac sarcoidosis will be enrolled.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Biopsy proven sarcoidosis
- •Suspected cardiac sarcoidosis
排除标准
- •Contraindication to MRI
结局指标
主要结局
Pulmonary mortality
时间窗: > 1year
only in subset of patients with pulmonary sarcoidosis
cardiac mortality
时间窗: > 1year
arrhythmic death
时间窗: > 1year
次要结局
- Cardiac Transplant(> 1 year)
- all-cause mortality(> 1year)
- Pulmonary Transplant(> 1 year)
- arrhythmic events(> 1year)
- PPM placement/high grade AV block(> 1 year)