Detection and Prognostic Significance of Myocardial Damage Visualized by Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sarcoidosis
- Sponsor
- Duke University
- Enrollment
- 27000
- Locations
- 1
- Primary Endpoint
- Pulmonary mortality
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
The primary objective of this study was to determine the ability of cardiac magnetic resonance (CMR) to identify cardiac involvement in patients with sarcoidosis. Patients were to undergo CMR in addition to routine clinical evaluation.
Detailed Description
In patients with sarcoidosis, cardiac death is a leading cause of mortality which may represent unrecognized cardiac involvement. Cardiovascular magnetic resonance (CMR) can detect cardiac involvement including minute amounts of myocardial damage. Therefore, the objective of this study was to determine the usefulness of CMR and compare it with standard clinical evaluation for cardiac involvement. Patients with documented extracardiac sarcoidosis or clinically suspected cardiac sarcoidosis will be enrolled.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Biopsy proven sarcoidosis
- •Suspected cardiac sarcoidosis
Exclusion Criteria
- •Contraindication to MRI
Outcomes
Primary Outcomes
Pulmonary mortality
Time Frame: > 1year
only in subset of patients with pulmonary sarcoidosis
cardiac mortality
Time Frame: > 1year
arrhythmic death
Time Frame: > 1year
Secondary Outcomes
- Cardiac Transplant(> 1 year)
- all-cause mortality(> 1year)
- Pulmonary Transplant(> 1 year)
- arrhythmic events(> 1year)
- PPM placement/high grade AV block(> 1 year)