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Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis

Recruiting
Conditions
Sarcoidosis
Registration Number
NCT01745237
Lead Sponsor
Duke University
Brief Summary

The primary objective of this study was to determine the ability of cardiac magnetic resonance (CMR) to identify cardiac involvement in patients with sarcoidosis. Patients were to undergo CMR in addition to routine clinical evaluation.

Detailed Description

In patients with sarcoidosis, cardiac death is a leading cause of mortality which may represent unrecognized cardiac involvement. Cardiovascular magnetic resonance (CMR) can detect cardiac involvement including minute amounts of myocardial damage. Therefore, the objective of this study was to determine the usefulness of CMR and compare it with standard clinical evaluation for cardiac involvement. Patients with documented extracardiac sarcoidosis or clinically suspected cardiac sarcoidosis will be enrolled.

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
27000
Inclusion Criteria
  • Biopsy proven sarcoidosis
  • Suspected cardiac sarcoidosis
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Exclusion Criteria
  • Contraindication to MRI
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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Pulmonary mortality> 1year

only in subset of patients with pulmonary sarcoidosis

cardiac mortality> 1year
arrhythmic death> 1year
Secondary Outcome Measures
NameTimeMethod
Cardiac Transplant> 1 year
all-cause mortality> 1year
Pulmonary Transplant> 1 year
arrhythmic events> 1year
PPM placement/high grade AV block> 1 year

Trial Locations

Locations (1)

Duke University Medical Center

🇺🇸

Durham, North Carolina, United States

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