Cardiovascular Imaging in Pediatric Myocarditis

• Conditions: Myocarditis

• Registration Number: NCT06652399
• Lead Sponsor: West China Second University Hospital

Brief Summary

This study aims to utilize cardiac magnetic resonance (CMR) to assist in the clinical diagnosis, conduct consecutive assessments for myocardial tissue in pediatrics with myocarditis, and explore effective predictive factors for adverse outcomes in pediatric myocarditis.

Participants will undergo baseline collection, laboratory tests, echocardiography, and CMR. All the consecutive data will be used to analyze the association with the diagnosis and prognosis of pediatric myocarditis.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-11-01
• Status Verified: 2024-10
• Study First Submitted: 2024-10-19
• Study First Submitted QC: 2024-10-19
• Last Update Submitted: 2024-10-19
• Study First Posted: 2024-10-22
• Last Update Posted: 2024-10-22
• Primary Completion: 2032-11-01
• Study Completion: 2033-04-01

Recruitment & Eligibility

• Status: ENROLLING_BY_INVITATION
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients diagnosed or suspected pediatric myocarditis based on Diagnostic Recommendation for Myocarditis in Children (version 2018).
• Age between 1 to 18 years old.

Exclusion Criteria

• Previous history of cardiovascular disease ( e.g. congenital heart disease, cardiomyopathy, rheumatic heart disease, valvular disease ).
• MRI examination contraindications ;
• Gadolinium contrast agent contraindications ;
• CT examination contraindications ;
• Comparison of iodine content.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Adverse cardiovascular events	10 years after the onset	including all-cause death, orthotopic heart transplantation(HTx), malignant arrhythmia, readmission due to heart failure, progression to DCM.

Secondary Outcome Measures

Name	Time	Method
Secondary cardiovascular adverse events	10 years after the onset	including mild reduction of cardiac function, persistent mild AVB and other arrhythmias, left chest tightness, palpitations and other clinical symptoms.

Trial Locations

Locations (1)

West China Second University Hospital, Sichuan University; 🇨🇳 Chengdu, Sichuan, China