NL-OMON38302
Recruiting
Not Applicable
Blood-brain barrier permeability and cerebral perfusion in Alzheimer*s disease - Vascular dysfunction in AD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- neurodegeneratieve aandoeningen
- Sponsor
- niversiteit Maastricht
- Enrollment
- 60
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients with AD:
- •Informed consent before participation in the study
- •Received standard diagnostic procedure according to the Parelsnoer Initiative procedure
- •Diagnosed with dementia of the Alzheimer\*s type
- •Clinical dementia rating (CDR) of 1, which means a mild to moderate stage of dementia
- •MMSE \>\= 20 and patients are mentally competent This inclusion criterion is conform the Parelsnoer Initiative inclusion criteria. By the Parelsnoer Initiative, individuals with an MMSE \>\=18 are considered mentally competent.;Patients with prodromal AD:
- •Informed consent before participation in the study
- •Received standard diagnostic procedure according to the Parelsnoer Initiative procedure
- •Diagnosis of prodromal dementia according to the Dubois criteria (16\)
- •CDR of 0\.5, which suggests a very mild stage of dementia
Exclusion Criteria
- •Contraindications for scanning (e.g. brain surgery, cardiac pacemaker, metal implants, claustrophobia, large body tattoos)
- •Contraindications for contrast agent Gadovist (renal failure) as determined by the estimated Glomular Filtration Rate eGFR \< 30 mL/min.
- •Major vascular disorders (e.g. stroke, heart disease)
- •Psychiatric or neurological disorders (e.g. Major depression; history of schizophrenia; bipolar disorder; psychotic disorder NOS or treatment for a psychotic disorder; cognive impairment due to alcohol abuse; epilepsy, Parkinson\*s disease, MS, brain surgery, brain trauma, electroshock therapy, kidney dialysis, Meniere\*s disease, brain infections)
- •Structural abnormalities of the brain
- •Cognitive impairment due to alcohol/drug abuse
- •Absence of reliable informant (for AD patient groups)
Outcomes
Primary Outcomes
Not specified
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