ISRCTN17419165
Active, not recruiting
未知
Blood-brain barrier permeability, inflammation, and clinical progression in Alzheimer's disease
niversity of Southampton0 sites70 target enrollmentMay 21, 2024
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- niversity of Southampton
- Enrollment
- 70
- Status
- Active, not recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Age \> 50 years old, no upper limit.
- •2\. Able and willing to give informed consent for participation in the study at baseline.
- •3\. AD participants: meet international consensus criteria for a diagnosis of AD dementia or mild cognitive impairment secondary to AD.
- •Control participants: no cognitive impairment and a MoCA score greater than, or equal to, 26 at baseline.
Exclusion Criteria
- •1\. Lack capacity to provide informed consent at baseline or decline to participate.
- •2\. Not proficient in English language.
- •3\. Absence of a reliable study partner (AD participants only).
- •4\. Diagnosis of mixed dementia or another central nervous system disease (e.g. multiple sclerosis, stroke).
- •5\. Intercurrent acute kidney injury, infection, or delirium.
- •6\. History or presence of major psychiatric disorder or alcohol/substance misuse, within the last two years.
- •7\. Diagnosis of any severe inflammatory disorder (e.g. rheumatoid arthritis, periodontitis, inflammatory bowel disease, chronic/recurrent gingivitis).
- •8\. Use of non\-topical steroids or cytokine modulators.
- •9\. Previous brain imaging showing confluent white matter changes reflective of gross cerebrovascular disease.
- •10\. Impaired renal function that absolutely contraindicates contrast\-enhanced MRI (eGFR \< 40\).
Outcomes
Primary Outcomes
Not specified
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