Microcirculation of the Thenar Eminence

Completed

• Conditions: Elective Cardiac Surgery
• Interventions: Other: microcirculatory reactivity

• Registration Number: NCT01748266
• Lead Sponsor: Centre Hospitalier Universitaire de Saint Etienne

Brief Summary

Microcirculatory disturbances following cardiac surgery with cardiopulmonary bypass (CPB) have been thought to be at the origin of organ dysfunction. Though, few studies correlated microvascular alterations with outcome. Investigators aimed at firstly describing microcirculation with near infra red spectroscopy (NIRS) and secondly correlating NIRS parameters with intensive care length of stay and organ dysfunction.

Detailed Description

40 patients at high risk of post operative systemic inflammatory response syndrome after an elective cardiac surgery with CPB were included in this prospective observational study. Patients were studied during the first 48 postoperative hours. Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge. Organ dysfunction was assessed with the SOFA score.

Study Timeline

• Study Start: 2010-04
• Primary Completion: 2011-08
• Study Completion: 2011-08
• Status Verified: 2012-12
• Study First Submitted: 2012-12-07
• Study First Submitted QC: 2012-12-11
• Last Update Submitted: 2012-12-11
• Study First Posted: 2012-12-12
• Last Update Posted: 2012-12-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Age > 18 years
• scheduled for an elective cardiac surgery at high risk of post operative systemic inflammatory response syndrome

Exclusion Criteria

• BMI>35

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
microcirculatory reactivity	microcirculatory reactivity	Patients were studied during the first 48 postoperative hours. Microcirculation of the thenar eminence was analyzed by NIRS technology, through the StO2 and the resaturation slope after an ischemic challenge.

Primary Outcome Measures

Name	Time	Method
microcirculatory reactivity	10 minutes before anesthésia induction	Tissue oxygen saturation (StO2) measure by a tissue spectrometer with a 25 mm probe spacing placed on the thenar eminence

Secondary Outcome Measures

Name	Time	Method
microcirculatory reactivity	during CPB (30 minutes after the start), and 2, 6, 12, 24 and 48 hours after the end of the CPB	Tissue oxygen saturation (StO2) measure by a tissue spectrometer with a 25 mm probe spacing placed on the thenar eminence

Trial Locations

Locations (1)

Chu Saint-Etienne; 🇫🇷 Saint-etienne, France