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临床试验/CTRI/2025/02/080597
CTRI/2025/02/080597尚未招募不适用

Effect of volume and pressure controlled ventilation on arterial to end-tidal carbondioxide gradient P(a-ET)CO2 in patients undergoing robotic lower abdominal oncological surgery in the trendelenburg position :a randomised prospective comparative study

DR NISHANTHI M1 个研究点 分布在 1 个国家目标入组 42 人开始时间: 2025年2月15日最近更新:

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
42
试验地点
1
主要终点
To assess the effects of two different ventilatory modes, PCV and VCV on Arterial to end tidal carbondioxide gradient P(a-ET) CO2 in patients undergoing elective robotic lower abdominal and pelvic oncological surgery

研究概览

简要总结

THIS IS RANDOMISED PROSPECTIVE COMPARATIVE STUDY COMPARING THE EFFECTS OF VOLUME CONTROLLED VENTILATION (VCV) AND PRESSURE CONTROLLED VENTILATION (PCV) ON ARTERIAL TO END TIDAL CARBONDIOXIDE GRADIENT IN PATIENTS UNDERGOING ROBOTIC LOWER ABDOMINAL ONCOLOGICAL SURGERY IN THE TRENDELENBERG POSITION . PATIENTS WILL BE RANDOMISED INTO EITHER GROUP PCV OR GROUP VCV AND FROM THE ARTERIAL BLOOD SAMPLE ARTERIAL BLOOD GAS ANALYSIS WILL BE DONE AND BASELINE VALUES WILL BE NOTED. PRIMARY OBJECTIVE IS TO ASSESS THE EFFECTS OF TWO DIFFERENT VENTILATORY MODES , PCV AND VCV ON ARTERIAL TO END TIDAL CARBONDIOXIDE GRADIENT IN THESE PATIENTS. SECONDARY OBJECTIVE IS TO COMPARE THE EFFECTS OF VCV AND PCV IN PEAK AIRWAY PRESSURE (Paw),DYNAMIC COMPLIANCE (Cdyn),ALVEOLAR TO ARTERIAL OXYGEN GRADIENT (P(A-a)O2),HEMODYNAMICS AND TO MEASURE ALVEOLAR DEAD SPACE FRACTION (AVDSF) BY MODIFIED BOHRS EQUATION IN ELECTIVE ROBOTIC LOWER ABDOMINAL AND PELVIC ONCOLOGICAL SURGERY.

研究设计

研究类型
Interventional
分配方式
Na
盲法
None

入排标准

年龄范围
18.00 Year(s) 至 65.00 Year(s)(—)
性别
All

入选标准

  • 1.ASA Grade I & II 2.Patients with BMI between 18.5 AND 30kg/m2 3.Patients undergoing elective Robotic lower abdominal and pelvic surgery in the trendelenberg position.

排除标准

  • 1.Patient refusal 2.BMI more than35 3.Chronic smokers 4.Documented chronic obstructive pulmonary disease.
  • 5.Increased Pulmonary artery pressure in Echocardiography 6.Poor cardiac reserve 7.Asthma or other chronic lung diseases.

结局指标

主要结局

To assess the effects of two different ventilatory modes, PCV and VCV on Arterial to end tidal carbondioxide gradient P(a-ET) CO2 in patients undergoing elective robotic lower abdominal and pelvic oncological surgery

时间窗: 10HOURS

次要结局

  • To compare the effects of VCV & PCV in Peak airway pressure (Paw),Dynamic compliance (Cdyn),Alveolar to arterial oxygen gradient (P(A-a)O2),Hemodynamics & to measure Alveolar dead space fraction (AVDSF) by modified Bohrs equation in elective robotic lower abdominal & pelvic oncological surgery(10 HOURS)

研究者

发起方
DR NISHANTHI M
申办方类型
Other [self]
责任方
Principal Investigator
主要研究者

Nishanthi M

Kidwai memorial Institute of oncology

研究点 (1)

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