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Patient Characteristics and Treatment Patterns From Early Crizanlizumab Use in Real-world Setting: Preliminary Analysis From Select Sickle Cell Centers

Completed
Conditions
Sickle Cell Disease
Registration Number
NCT05833022
Lead Sponsor
Novartis Pharmaceuticals
Brief Summary

This was a retrospective cohort study using secondary data from member sites of the National Alliance of Sickle Cell Centers (NASCC) with at least five patients who initiated crizanlizumab. Patients who were prescribed crizanlizumab were included in the cohort.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
297
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Percentage of patients who received sickle cell disease treatment (use of hydroxyurea, l-glutamine, chronic transfusion therapy, and voxelotor) during treatment with crizanlizumabUp to 12 months
Percentage of patients who received sickle cell disease treatment (use of hydroxyurea, l-glutamine, chronic transfusion therapy, and voxelotor) prior to treatment with crizanlizumabUp to 12 months
Secondary Outcome Measures
NameTimeMethod
Number of doses of crizanlizumab for patients who discontinued treatment with crizanlizumabUp to 24 months
Number of sickle cell disease (SCD)-related hospitalizationsUp to 24 months
Number of patients who discontinued treatment with crizanlizumabUp to 24 months
Reasons for early discontinuation of crizanlizumab treatmentUp to 24 months
Number of SCD-related emergency department (ED) visitsUp to 24 months

Trial Locations

Locations (11)

University of Alabama Birmingham

🇺🇸

Birmingham, Alabama, United States

Cristiana Care

🇺🇸

Wilmington, Delaware, United States

All Children's Hospital

🇺🇸

Saint Petersburg, Florida, United States

Washington University of St. Louis

🇺🇸

Saint Louis, Missouri, United States

Johns Hopkins University

🇺🇸

Baltimore, Maryland, United States

Beth Israel Hospital

🇺🇸

East Hanover, New Jersey, United States

Montefiore

🇺🇸

New York, New York, United States

University of North Carolina

🇺🇸

Chapel Hill, North Carolina, United States

University Hospital at Cleveland Medical Center

🇺🇸

Cleveland, Ohio, United States

Ohio State University

🇺🇸

Columbus, Ohio, United States

University of Texas (Houston)

🇺🇸

Houston, Texas, United States

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