Bronchial Artery Embolization in the Management of Hemoptysis

STUDY DESIGN:Prospective observational study. TIME FRAME / DURATION: 2YEARS METHODOLOGY: The study will be conducted after approval from the institutional ethical committee in our institution, a tertiary care hospital, for two years. Patients presenting with massive Hemoptysis referred to our department will be included for bronchial artery embolization. Massive Hemoptysis is defined as bleeding more than 600ml / 24 hr. All patients will have a chest x-ray to lateralize the side of the bleeding. HRCT thorax will be done in some patients to know further about the lesions and bronchial and non-bronchial feeders before embolization. SAMPLE SIZE CALCULATION : Expected Sensitivity: 0.97 (13) Expected specificity: 0.91 (13) Prevalence of disease: 0.30 (14) Precision (± expected): 0.08 Confidence level 100(1- α): 95% Expected dropout rate: 5% Final Sample size (with 5% dropout) = 75 Statistical Analysis Data will be entered into a Microsoft Excel sheet, and statistical analysis will be done on the statistical software STATA 12. For descriptive statistics, mean ± standard deviation will be used, a median and interquartile range for quantitative variables, and a percentage with a number for categories. The relationship between various demographic, clinical characteristics and echocardiography diagnoses with the outcome will be evaluated by deploying the Chi-square test, Fischer’s exact test for categorical data, and an independent t-test for continuous data with normal distribution. Spearman (parametric) or Pearson (non-parametric) correlations will be applied to determine the association between dependent and independent variables. The p-value will be considered significant if less than 0.05.