The Relationship between cardiovascular disease and Brachial-ankle Pulse Wave Velocity(baPWV) in Patients with Type 2 Diabetes (REBOUND study)
- Conditions
- Endocrine, nutritional and metabolic disease
- Registration Number
- KCT0005010
- Lead Sponsor
- Pusan National University Hospital
- Brief Summary
We found that a high-baPWV can predict all-cause and cause-specific mortality in subjects with type 2 diabetes. Our study is the first using a long-term and large-scale prospective cohort to present the appropriate baPWV cutoff point for cause-specific mortality, and demonstrates the predictive role of baPWV for cancer prognosis independent of conventional risk factors in people with type 2 diabetes. The measurement of baPWV as a noninvasive tool for arterial stiffness is useful for assessing mortality risk and, furthermore, 1,900 cm/s may be considered the optimal value for mortality risk assessment in type 2 diabetic patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 2333
The inclusion criteria for patients
(i) patients with type 2 diabetes who were 30 years of age or older
(ii) baseline baPWV measured
(i) type 1 diabetes mellitus;
(ii) an ankle brachial index (ABI) of <0.9
(iii) severe symptoms and/or signs of Cardiovascular disease
(iv) hospitalization within the previous three months due to acute myocardial infarction, stroke, or heart failure;
(v) chronic kidney disease (serum creatinine levels >2.0 mg/dL)
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause and cause-specific mortality by Ankle-brachial pulse wave velosity
- Secondary Outcome Measures
Name Time Method Optimal cutoff value of Ankle-brachial pulse wave velosity