Elucidating the high cardiovascular disease risk in South Asians: focus on monocyte phenotype and incretin hormones
- Conditions
- cardiovascular diseases1001842410003216
- Registration Number
- NL-OMON56245
- Lead Sponsor
- Interne Geneeskunde
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 48
- Males and females of South Asian or Dutch European ethnicity
- Age from 18 to 30 years old
- BMI 18 - 25 kg/m2
- Capable of giving informed consent
- (auto-) immune disease(s) including type 1 or 2 diabetes mellitus, chronic
kidney disease, hepatic disease, inflammatory bowel disease, thyroid disease
and rheumatoid arthritis. - Genetic lipid-associated disorders such as familial
hypercholesterolemia - Any chronic renal or hepatic disease - Use of medication
known to influence glucose and/or lipid metabolism (e.g. beta-blockers,
antidepressants, corticosteroids) - Abuse of alcohol or other substances -
Smoking - Vigorous exercise (>3 times/week) - Milk or soy allergy -
Contrainindications for the InBody720 scan, such as a pacemaker - Participation
in an intensive weight loss program or vigorous exercise program during the
last year before the start of the study - laboratory abnormalities that could
point towards an underlying disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. To compare immune cell composition between lean adolescent Dutch South Asian<br /><br>and BMI- and age-matched Dutch Europids<br /><br>2. To compare the monocyte phenotype between lean adolescent Dutch South Asian<br /><br>and BMI and age-matched Dutch Europids<br /><br>3. To compare functional and metabolic characteristics of monocytes between<br /><br>lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids</p><br>
- Secondary Outcome Measures
Name Time Method <p>4. To compare glucocorticoid receptor sensitivity between lean adolescent Dutch<br /><br>South Asian and BMI- and age-matched Dutch Europids<br /><br>5. To compare the release of incretins (GLP-1 and GIP) during a mixed meal<br /><br>tolerance test (MMTT) between lean adolescent Dutch South Asian and BMI- and<br /><br>age-matched Dutch Europids<br /><br>6. To compare markers of glucose metabolism (glucose, insulin, C-peptide)<br /><br>during an MMTT between lean adolescent Dutch South Asian and BMI- and<br /><br>age-matched Dutch Europids<br /><br>7. To compare markers of lipid metabolism (free fatty acids (FFA),<br /><br>triglycerides (TG), high-density-lipoprotein (HDL), total cholesterol) during<br /><br>an MMTT between lean adolescent Dutch South Asian and BMI- and age-matched<br /><br>Dutch Europids</p><br>