Dual Wavelength OCT

Completed

• Conditions: Diabetic Retinopathy; Retinal Degeneration; Retinal Dystrophies; AMD
• Interventions: Device: Combined Coaxial Optical Coherence Tomography

• Registration Number: NCT03843840
• Lead Sponsor: Moorfields Eye Hospital NHS Foundation Trust

Brief Summary

The purpose of this research is the evaluation of a combined coaxial optical coherence tomography (OCT) system to image retina/choroid and to evaluate if post processing of the data can give us insights into property of the tissue imaged.

Detailed Description

Histology studies have shown that many disorders of the retina and choroid such as age-related macular degeneration is associated with a build up abnormal deposits, in the retina or subretinal space. Being able to detect subtle changes in retina and choroidal structure is crucial for better understanding and monitoring of this potentially blinding condition. This study aims to commercially available Spectralis® OCT-system with a central wavelength of 880nm explore the ability of a confocal scanning laser ophthalmoscope (cSLO) for OCT imaging utilising a modified by the addition of a longer wavelength OCT (1075nm , a wavelength deployed on other commercially available OCT scanners). Other commercially available OCT scanners used longer wavelengths to allow deeper penetration and enhanced visualisation of subretinal tissue but less inner retinal detail. Combing both wavelengths could have the advantage of allowing optimum viualisation of inner and subretinal structures. The ability of the systems to acquire repeatable and good quality images of retinal and choroidal structural detail at matching location and compare the results from the two instruments will be evaluated. In addition processing of the images reflectivity with two different wavelength should give us insight into the nature of any abnormal material.

Study Timeline

• Study First Submitted: 2018-05-31
• Study Start: 2019-02-15
• Study First Submitted QC: 2019-02-15
• Study First Posted: 2019-02-18
• Primary Completion: 2019-11-30
• Study Completion: 2020-10-21
• Status Verified: 2022-04
• Last Update Submitted: 2022-04-04
• Last Update Posted: 2022-04-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age>18
• Ability to consent
• Abnormal reflectivity detected in at least one eye in the retina or choroid on OCT testing undertaken as part of routine
• clinical care

Exclusion Criteria

• Media opacities on conventional OCT testing taken on the day of the study visit, that prevents adequate visualisation of
• the retina and/or choroidal substructures in the opinion of the investigator
• Inability to undertake to undertake two additional OCT scans on each eye in addition to their conventional OCT.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Diseased Retina	Combined Coaxial Optical Coherence Tomography	-

Primary Outcome Measures

Name	Time	Method
Test retest reliability	14 months	Comparison of device test retest variability with those of standard OCT for measurement of tissue reflectivity.

Trial Locations

Locations (1)

Moorfields Eye Hospital NHS Foundation Trust, 162 City Road; 🇬🇧 London, United Kingdom