Risk Factors for Refeeding Syndrome in the Surgical Intensive Care Unit

Recruiting

• Conditions: Refeeding Syndrome
• Interventions: Other: Refeeding Syndrome

• Registration Number: NCT06054139
• Lead Sponsor: Samsun University

Brief Summary

Refeeding Syndrome is a condition that occurs when patients who are undernourished or undernourished suddenly start overfeeding, causing electrolyte disturbances and vitamin deficiencies, resulting in neurological and cardiac problems. It may even result in death. It is aimed to prevent the development of Refeeding Syndrome with nutrition in accordance with the guidelines. The aim of this study is to determine the risk factors for Refeeding Syndrome in Intensive Care Unit (ICU).

Detailed Description

Nutritional support is an important part of treatment in intensive care patients. Especially existing comorbidities and developing acute problems before intensive care admission can cause serious malnutrition for patients. Refeeding syndrome is a serious, life-threatening condition accompanied by electrolyte and metabolic disorders as a result of rapid re-feeding following prolonged starvation or malnutrition. The condition may be accompanied by electrolyte disorders such as hypophosphatemia, hypokalemia and hypomagnesemia, as well as decrease in vitamin levels (especially vitamin B1), fluid imbalance and salt retention. The resulting imbalances can cause cardiac and neurological side effects, impaired organ functions and even death. The refeeding protocol should be individualized to each patient's clinical situation. In this study, although nutritional protocols in accordance with the guidelines are applied in patients with risk factors for the development of Refeeding Syndrome, whether Refeeding Syndrome develops and the facilitating factors will be investigated in ICU.

Study Timeline

• Study Start: 2023-06-09
• Status Verified: 2023-09
• Study First Submitted: 2023-09-19
• Study First Submitted QC: 2023-09-19
• Last Update Submitted: 2023-09-19
• Study First Posted: 2023-09-26
• Last Update Posted: 2023-09-26
• Primary Completion: 2024-06-09
• Study Completion: 2024-07-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Patients are intensive care patients
2. Patients' age > 18 -

Exclusion Criteria

1. Diabetic ketoacidosis
2. Other risk factors for hypophosphatemia (patients on continuous hemodialysis, hyperphosphatemia treatment, parathyroidectomy)
3. Patients with pre-study hypophosphatemia (< 0.65 mmol/L)
4. Patients with hyperparathyroidism
5. Terminal stage cancer patients
6. Patients with Glasgow Coma Scale ≤5
7. Patients with respiratory and metabolic alkalosis -

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
the treated patients in ICU	Refeeding Syndrome	Patients receiving nutrition while receiving treatment in intensive care

Primary Outcome Measures

Name	Time	Method
Occurrence of Refeeding Syndrome	from june 9, 2023 to june 9, 2024	Occurrence of RFS：Within 72 hours after feeding serum phosphorus \< 0.0.87mmol/L, or from the baseline levels drop \> 0.16% or drop \> 30%;And (or) hypokalemia, hypomagnesemia, hypocalcemia and corresponding clinical symptoms

Trial Locations

Locations (1)

Şerife Seçgin; 🇹🇷 Samsun, Turkey