Dynamic Changes in Some Facial Muscles After Superficial Versus Deep Hyaluronic Acid Injection: An Electromyographic Study
Overview
- Phase
- Early Phase 1
- Sponsor
- Alexandria University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- electrophysiological changes in some facial muscles
Overview
Brief Summary
assess electrophysiological changes in some facial muscle dynamics following hyaluronic acid filler injection in superficial versus deep level of injection.
Detailed Description
Participants will be subjected to injection of cross-linked hyaluronic acid fillers on both sides of the face in 3 different regions: temples, cheeks and chins.
Each female will undergo:
-
Before injection:
-
Aesthetic facial clinical analysis.
-
Baseline quantitative surface electromyography.
-
Baseline digital photography.
-
Injection:
Each female will receive the injection in the particular facial region at superficial level to the muscle (subcutaneous) on one side and the same amount at deep level to the muscle (supraperiosteal) on the other side. 3. One week after injection:
- Follow up quantitative surface electromyography.
- Follow up digital photography.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to 60 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age: 20-60 years.
- •Sex: females.
- •Areas eligible for injection: temples, cheeks and chin.
Exclusion Criteria
- •Active infection near the site of injection.
- •Pregnant or lactating women.
- •Patients suffering from any neuromuscular disorders.
- •Known allergy/hypersensitivity to hyaluronic acid fillers.
- •History of botulinum toxin injection in the last 4 months.
- •History of injection of fillers in the last 2 years.
- •Patients receiving any muscle relaxants.
- •Coagulation disorder or anticoagulants therapy.
Arms & Interventions
deep injection of hyaluronic acid fillers
Each female will receive filler injection deep to the muscle (supraperiosteal) on one side of the face.
Intervention: hyaluronic acid filler injection (Drug)
superficial injection of hyaluronic acid fillers
Each female will receive filler injection at superficial level to the muscle (subcutaneous) on the contralateral side(same dose and same site).
Intervention: hyaluronic acid filler injection (Drug)
Outcomes
Primary Outcomes
electrophysiological changes in some facial muscles
Time Frame: one week
baseline and follow up quantitative surface electromyography
Secondary Outcomes
No secondary outcomes reported
Investigators
marwa eldeeb
lecturer of dermatology
Alexandria University