Compare the Operating Condition of Two Levels of Muscle Relaxation on Facial Nerve MEP Monitoring in CPA Surgery
- Conditions
- Cerebellopontine Angle Tumor
- Interventions
- Drug: Rocroniom, Non Depolarizing Muscle Relaxant
- Registration Number
- NCT04148534
- Lead Sponsor
- Muhammad Magdy Gaber
- Brief Summary
compare the operating condition of two different levels of muscle relaxation on facial nerve monitoring using transcranial motor evocked potential in CPA surgery .
* To Estimate End to start facial nerve MEP amplitude ratio
* To determine the effect of neuromuscular relaxant degrees on recovery and
* Assessment of propofol doses needed for enhancement of early recovery and ambulation.
- Detailed Description
40 Patients aged from 18-60 years old undergoing Cerebellopontine angle surgery. Patients will be one of two groups: Both Induction will be accomplished with fentanyl, propofol , rocronium infusion will be given randomly to one of the groups.
Depth of anaesthesia, neurotransmitter monitoring and facial nerve neurophysiological monitoring will be done.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Patients age between >18 and<60.
- Patients scheduled for neurosurgical CPA surgeries
- Ability to sign the consent
- ASA classification I, II
- ASA > II
- Hemodynamically unstable
- Disease affecting neuromuscular transmission (myasthenia gravies ...etc.)
- GCS < 15.
- Any cardiac patient (ischemic heart disease - cardiomyopathy...etc.)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description muscle relaxant Rocroniom, Non Depolarizing Muscle Relaxant patient who will receive muscle relaxant, patients will receive rocronium infusion by (5 mcg/kg/min) , maintain partial NMB TOF count 2 and targeting BIS = (40-60) without muscle relaxant Rocroniom, Non Depolarizing Muscle Relaxant patient who will not receive muscle relaxant, will recieve normal saline targeting BIS = 40-60.
- Primary Outcome Measures
Name Time Method End to start facial nerve MEP amplitude ratio. 6 to 8 month TCMEP recording will begin (1) prior to skin incision as baseline amplitude before muscle relaxant be taken for intubation (2) at Dural closure and end \\start amplitude ratio will be calculated.
- Secondary Outcome Measures
Name Time Method number of hypotension episodes and the use of vasopressors 6 to 8 month hemodynamic condition
Total volume of propofol and fentanyl infused 6 to 8 month Calculate dose consumption
Trial Locations
- Locations (1)
Cairo university medical school
🇪🇬Cairo, Egypt