Clinico-immunological Characterization and Immune Tolerance Breakdown in HU-autoimmunity
Active, not recruiting
- Conditions
- Immune Tolerance
- Interventions
- Other: Description of clinical, immunological and tumor features of patients harboring Hu Abs
- Registration Number
- NCT05745792
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
Phenotypic characterization of patients with Hu-Abs, including the different neurological presentation and the presence or not of an underlying cancer.
Analysis and clinical correlation of the diagnostic techniques for Hu-Abs detection (immunofluorescence, immunodot/Western blot, and CBA) in serum and/or CSF.
Genomic and transcriptomic features of tumors (histological and immune infiltrate characteristics, transcriptomic profile, mutational status).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 400
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients with Hu Abs Description of clinical, immunological and tumor features of patients harboring Hu Abs Patients harboring Hu Abs and a neurological syndrome
- Primary Outcome Measures
Name Time Method Modified Rankin Scale (mRs) At 1 year Application of modified rankin scale
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites autoimmunes
🇫🇷Lyon, France