Platelet Transfusions in Critically Ill Patient

• Conditions: Platelet Transfusion; Critical Illness

• Registration Number: NCT03325140
• Lead Sponsor: University Hospital, Brest

Brief Summary

Between 10 and 15% of critically ill patients require platelet transfusion within their intensive care unit (ICU).

Platelets (PLT) are given to prevent bleeding in thrombocytopenic patients or to treat bleeding as part of massive transfusion or in bleeding thrombocytopenic patients.

International and local guidelines (American Association of Blood Banks-AABB) are mainly based on experts' opinion. The efficacy of PLT transfusion in the ICU setting remains poorly studied and unknown and the administration of PLT may be associated with adverse effects including an increased risk of hospital acquired infection. Finally, the short PLT shelve-life may be responsible for inventory issues. Altogether, this makes very important to improve the evidence that support PLT transfusion in ICU patients.

This is a multicentre prospective observational study that aims to first determine PLT transfusion efficacy and to identify the parameters associated with transfusion efficacy and to analyse the compliance with international (and local) guidelines of PLT transfusion in ICU patients.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-10-21
• Study First Submitted QC: 2017-10-27
• Study First Posted: 2017-10-30
• Study Start: 2018-05-30
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-16
• Last Update Posted: 2019-07-18
• Primary Completion: 2019-12-15
• Study Completion: 2019-12-15

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Patients admitted to intensive care and receiving at least one platelet transfusion in intensive care unit

Exclusion Criteria

• Age less than 18

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
platelet transfusion efficacy	between 18 hours and 28 days after transfusion	corrected count platelet increment

Trial Locations

Locations (7)

CHU d'Angers; 🇫🇷 Angers, France

CHU de Rennes; 🇫🇷 Rennes, France

CHU de Nantes; 🇫🇷 Nantes, France

CHU de Tours; 🇫🇷 Tours, France

CHRU de Brest; 🇫🇷 Brest, France

CH des Pays de Morlaix; 🇫🇷 Morlaix, France

Chba Site de Vannes; 🇫🇷 Vannes, France