The Effect of Gastric Bypass Surgery on the Beta- and Alpha Cells Secretory Function and the Insulinotropic Effect of the Incretin Hormones
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 11
- 试验地点
- 1
- 主要终点
- Change in beta cell function
研究概览
简要总结
The study aims at describing the acute and subacute changes after Roux-en-Y (RYGB) gastric bypass in insulin secretion from the beta cell and glucagon secretion from the alpha cell as well as the stimulatory effect of the incretins on the pancreatic islets. RYGB is a bariatric procedure that changes the gastrointestinal anatomy and has been demonstrated to cause remission of type 2 diabetes shortly after the operation, before any significant weight loss. The altered transit of nutrient through the gastrointestinal tract after the operation is thought to play a key role in this remission and studies have shown significant changes in the secretion of gut hormones, namely the incretin hormone glucagon-like peptide-1 (GLP-1). However it is unknown whether the secretory function of the pancreatic islets as well as the stimulatory effect of the incretin hormones is changes postoperatively.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Normal glucose tolerance
- •Age > 18 years
- •BMI > 40 or > 35 if combined with hypertension or obstructive sleep apnoea
- •Caucasian
- •Normal hemoglobinaemia
- •Signed informed consent
排除标准
- •Major psychiatric disorder
- •Alcohol or drug abuse
- •Major hearth or pulmonary disease
- •Previous major abdominal disease (e.g. peritonitis, large hernia)
- •Pregnancy/lactation
- •Treatment with GLP-1 analogs
结局指标
主要结局
Change in beta cell function
时间窗: Before and 1 week and 3 months after surgery
Change in first and second phase insulin response, disposition index, and acute insulin secretion in response to a non-glucose stimulus
Insulinotropic effect of incretin hormones
时间窗: Before and 1 week and 3 months after surgery
Change in first and second phase insulin response during GLP-1 and GIP infusion compared to saline
次要结局
- Change in alpha cell function(Before and 1 week and 3 months after surgery)
研究者
Carsten Dirksen
MD PhD student
Hvidovre University Hospital