Ghrelin Changes After Roux-en-Y Gastric Bypass
Completed
- Conditions
- ObesityInsulin Resistance
- Interventions
- Other: Liquid diet for 3 days
- Registration Number
- NCT00765596
- Lead Sponsor
- Vanderbilt University
- Brief Summary
The purpose of this study is to determine whether gastric division (via Roux-en-Y gastric bypass) with resultant fundic isolation will alter the pattern(s) of Ghrelin secretion in the early post-operative period following feeding in morbidly obese subjects.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 14
Inclusion Criteria
- Serum creatinine and liver function tests < upper limits of normal
- Stable body weights for the past three months
- Women will have a negative pregnancy test
- patients who are already scheduled for RYGB with gastrostomy tube placement
Read More
Exclusion Criteria
- Significant hepatic enzyme elevations (more than 100% of upper limits of normal)
- Serum creatinine > 1.5 mg/dl
- history of ketoacidosis or current metabolic acidosis
- current use of oral anticoagulants
- Positive pregnancy test (beta-human chorionic gonadotrophin) for females
- intercurrent infections
- patients with prior gastric operations
Read More
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description 2 Matched controls Liquid diet for 3 days Subjects matched by BMI, age, gender to RYGB group
- Primary Outcome Measures
Name Time Method Ghrelin pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op
- Secondary Outcome Measures
Name Time Method HOMA pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op metabolic hormones pre-op, peri-op, immediately post-op, 2 days, 3 wks, 6wks, 6mos, 1 year post op
Trial Locations
- Locations (1)
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States