ARTEMIS Synovial Markers in Arthritis Childhood

Not Applicable

Completed

• Conditions: Septic Arthritis; Juvenile Idiopathic Arthritis
• Interventions: Procedure: Articular punction, salivary samples, blood sample

• Registration Number: NCT02505828
• Lead Sponsor: University Hospital, Montpellier

Brief Summary

The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial fluids of septic and inflammatory arthritis. The investigators will use for this analysis, proteomics, cytokine dosage and monocyte typing by flow cytometry analysis. The investigators will use one marker or a score with biological and clinical data to discriminate arthritis of infectious and inflammatory etiology.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-04
• Study First Submitted: 2015-06-22
• Study First Submitted QC: 2015-07-20
• Study First Posted: 2015-07-22
• Primary Completion: 2018-04
• Study Completion: 2018-04
• Status Verified: 2020-12
• Last Update Submitted: 2020-12-29
• Last Update Posted: 2020-12-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Septic arthritis with bacteriological identification
• Juvenile idiopathic arthritis beyond the ILAR definition
• Having acute arthritis requiring an articular draining
• Child benefiting from a national insurance scheme
• Collection of the consent of the parents or the legal representative

Exclusion Criteria

• Contraindication in an articular draining: platelet 50 000 / mm3, Rate of prothrombins lower than 70 %, activated partial thromboplastin times (APTT)> 1,5
• Treatment by biotherapy, corticoids or other immuno suppressor in the month preceding the articular draining.
• Treatment by antibiotic begun more than 24 hours before the draining.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Septic arthritis	Articular punction, salivary samples, blood sample	with bacteriological identification
Juvenile idiopathic arthritis	Articular punction, salivary samples, blood sample	beyond the ILAR (International League of Associations for Rheumatology) definition

Primary Outcome Measures

Name	Time	Method
Qualitative analysis of new biological markers (proteic, cytokine or cellular) that discriminate inflammatory and infectious arthritis.	1 day	Identify blood sampling biomarkers of Arthritis childhood

Trial Locations

Locations (1)

Hôpital Arnaud de Villeneuve; 🇫🇷 Montpellier, France