The Neural Correlates of and Effects of Methylphenidate on Acute Pain Dynamics
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Effect of methylphenidate on acute pain dynamics
研究概览
简要总结
This work aims to study the neural correlates and determinants of pain dynamics related to changes in a noxious stimulus.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •History of chronic pain
- •History of neurological diagnosis
- •History of psychiatric diagnosis
研究组 & 干预措施
Methylphenidate
干预措施: Methylphenidate (Drug)
Placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Effect of methylphenidate on acute pain dynamics
时间窗: 6 months
We will compare acute pain dynamics-i.e., the time series of pain visual analog scale ratings (0-100, where 0 = no pain and 100 = worst pain imaginable) obtained while delivering a changing noxious stimulus-during the methylphenidate condition to that of the placebo condition.
Nucleus accumbens activation with acute pain dynamics
时间窗: 6 months
We will regress the time course of nucleus accumbens BOLD activity onto the latent time series obtained from our valence competition model. This will be supported by regressing the nucleus accumbens time course onto the pain VAS time course, allowing our findings to be compared to standard analyses in the literature.
次要结局
未报告次要终点
研究者
Andrew Vigotsky
PhD Candidate
Northwestern University