Neural Correlates of Acute Pain Dynamics

Phase 2

Completed

• Conditions: Pain
• Interventions: Drug: Placebo; Drug: Methylphenidate

• Registration Number: NCT05669924
• Lead Sponsor: Northwestern University

Brief Summary

This work aims to study the neural correlates and determinants of pain dynamics related to changes in a noxious stimulus.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-19
• Study First Submitted: 2022-12-20
• Study First Submitted QC: 2022-12-30
• Study First Posted: 2023-01-03
• Status Verified: 2024-04
• Primary Completion: 2024-04-26
• Study Completion: 2024-04-26
• Last Update Submitted: 2024-04-30
• Last Update Posted: 2024-05-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

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Exclusion Criteria

• Pregnant
• History of chronic pain
• History of neurological diagnosis
• History of psychiatric diagnosis

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Placebo	Placebo	-
Methylphenidate	Methylphenidate	-

Primary Outcome Measures

Name	Time	Method
Effect of methylphenidate on acute pain dynamics	6 months	We will compare acute pain dynamics-i.e., the time series of pain visual analog scale ratings (0-100, where 0 = no pain and 100 = worst pain imaginable) obtained while delivering a changing noxious stimulus-during the methylphenidate condition to that of the placebo condition.
Nucleus accumbens activation with acute pain dynamics	6 months	We will regress the time course of nucleus accumbens BOLD activity onto the latent time series obtained from our valence competition model. This will be supported by regressing the nucleus accumbens time course onto the pain VAS time course, allowing our findings to be compared to standard analyses in the literature.

Trial Locations

Locations (1)

Northwestern University; 🇺🇸 Chicago, Illinois, United States