Electroencephalogram Studies of Intravenous Methylphenidate-Induced Emergence From General Anesthesia
Overview
- Phase
- Phase 1
- Intervention
- IV methylphenidate
- Conditions
- Active Emergence From General Anesthesia
- Sponsor
- Massachusetts General Hospital
- Primary Endpoint
- Response to methlyphenidate administration
- Status
- Withdrawn
- Last Updated
- 8 years ago
Overview
Brief Summary
The aim of this study is to test the hypothesis that methylphenidate actively induces emergence from propofol and sevoflurane general anesthesia in healthy volunteers.
Detailed Description
Basic science and clinical data suggest that activation of one or more of the brain's arousal pathways is a highly plausible way to induce active emergence from general anesthesia. The investigators have compelling experimental data demonstrating that methylphenidate is highly effective in actively inducing emergence from isoflurane and propofol general anesthesia in rodents. The available literature suggests that IV methylphenidate would be safe to administer to patients recovering from general anesthesia, and that in addition to promoting arousal, it would enhance breathing. Both of these effects would be highly desirable in patients recovering from general anesthesia.
Investigators
Ken Solt
Assistant Professor
Massachusetts General Hospital
Eligibility Criteria
Inclusion Criteria
- •Age 18-36 years
- •ASA classification 1 or 2
- •Normal body weight, BMI ≤ 30
- •Right handed
- •No history of taking stimulants
Exclusion Criteria
- •In general, patients will be excluded from the study if the state of their chronic health problems gives them an ASA physical status classification of 3 or beyond.
Arms & Interventions
Propofol
Subjects in this arm will receive propofol general anesthesia
Intervention: IV methylphenidate
Propofol
Subjects in this arm will receive propofol general anesthesia
Intervention: Placebo
Propofol
Subjects in this arm will receive propofol general anesthesia
Intervention: Propofol
Sevoflurane
Subjects in this arm will receive sevoflurane general anesthesia
Intervention: IV methylphenidate
Sevoflurane
Subjects in this arm will receive sevoflurane general anesthesia
Intervention: Placebo
Sevoflurane
Subjects in this arm will receive sevoflurane general anesthesia
Intervention: Sevoflurane
Outcomes
Primary Outcomes
Response to methlyphenidate administration
Time Frame: minutes to response, expected average is less than 10 minutes
The number of minutes from the administration of methylphenidate until subjects respond to verbal commands