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Sevoflurane

Generic Name
Sevoflurane
Brand Names
Sevorane, Sojourn, Ultane
Drug Type
Small Molecule
Chemical Formula
C4H3F7O
CAS Number
28523-86-6
Unique Ingredient Identifier
38LVP0K73A

Overview

Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Background

Sevoflurane is an ether inhalation anesthetic agent used to induce and maintain general anesthesia. It is a volatile, non-flammable compound with a low solubility profile and blood/gas partition coefficient. Sevoflurane was patented in 1972, was approved for clinical use in Japan in 1990, and approved by the FDA in 1996. Sevoflurane is three times more potent than desflurane, but has lower potency compared to halothane and isoflurane. Unlike other volatile anesthetics, sevoflurane has a pleasant odor and does not irritate the airway. The hemodynamic and respiratory depressive effects of sevoflurane are well tolerated, and most patients receiving this anesthetic agent present little toxicity. Therefore, it can be used for inhalational induction in adults and children for a wide variety of anesthetic procedures.

Indication

Sevoflurane is used for the induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery.

Associated Conditions

No associated conditions information available.

FDA Approved Products

Sevoflurane
Manufacturer:Baxter Healthcare Company
Route:RESPIRATORY (INHALATION)
Strength:250 mL in 250 mL
Approved: 2023/05/31
NDC:10019-655
Sevoflurane
Manufacturer:Baxter Healthcare Company
Route:RESPIRATORY (INHALATION)
Strength:250 mL in 250 mL
Approved: 2023/05/31
NDC:10019-651
SEVOFLURANE
Manufacturer:Baxter Healthcare Corporation
Route:RESPIRATORY (INHALATION)
Strength:250 mL in 250 mL
Approved: 2023/05/31
NDC:10019-657
Sevoflurane
Manufacturer:Sandoz Inc.
Route:RESPIRATORY (INHALATION)
Strength:250 mL in 250 mL
Approved: 2022/11/08
NDC:0781-6160
Ultane
Manufacturer:AbbVie Inc.
Route:RESPIRATORY (INHALATION)
Strength:250 mL in 250 mL
Approved: 2022/09/08
NDC:0074-4456

Singapore Approved Products

Sevoflurane Inhalation Anaesthetic Liquid 100%
Manufacturer:Baxter Healthcare Corporation
Form:INHALANT
Strength:1ml/ml
Online:Yes
Approved: 2009/11/26
Approval:SIN13741P
SEVORANE INHALATION
Manufacturer:AbbVie S.r.l.
Form:SOLUTION
Strength:100%
Online:Yes
Approved: 1995/07/25
Approval:SIN08264P
SOJOURN INHALATION ANAESTHETIC LIQUID 100%
Manufacturer:Piramal Critical Care Inc.
Form:INHALANT
Strength:100% v/v
Online:Yes
Approved: 2015/05/08
Approval:SIN14780P
NOREVELL INHALATION ANAESTHETIC LIQUID 100%
Manufacturer:PT. Novell Pharmaceutical Laboratories
Form:INHALANT
Strength:100%
Online:Yes
Approved: 2023/07/10
Approval:SIN16819P

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