SEVORANE INHALATION

SOLUTION

**Dosage and Administration** Vaporisers specifically calibrated for use with Sevoflurane should be used so that the concentration delivered can be accurately controlled. MAC (minimum alveolar concentration) values for Sevoflurane decrease with age and with the addition of nitrous oxide. The table below indicates average MAC values for different age groups.  **Premedication:** Premedication should be selected according to the need of the individual patient, and at the discretion of the anaesthetist. The use of anticholinergic drugs is a matter of choice. **Induction:** Anaesthesia can be induced in adults and children with Sevoflurane. Dosage should be individualised and titrated to the desired effect according to the patient’s age and clinical status. A short acting barbiturate or other intravenous induction agent may be administered followed by inhalation of Sevoflurane. (See also “Interactions” – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). Induction with Sevoflurane may be achieved in oxygen or in combination with oxygen-nitrous oxide mixtures. In adults inspired concentrations of up to 5% Sevoflurane usually produce surgical anaesthesia in less than 2 minutes. In children, inspired concentrations of up to 7% Sevoflurane usually produce surgical anaesthesia in less than 2 minutes. Alternatively, for induction of anaesthesia in unpremedicated patients, inspired concentrations of up to 8% Sevoflurane may be used. **Maintenance:** Surgical levels of anaesthesia may be sustained with concentrations of 0.5–3% Sevoflurane with or without the concomitant use of nitrous oxide (see also “Drug Interactions” – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). **Elderly:** As with other inhalation agents, lesser concentrations of Sevoflurane are normally required to maintain surgical anaesthesia. See above for MAC values. **Emergence:** Emergence times are generally short following Sevoflurane anaesthesia. Therefore, patients may require early post-operative pain relief.