Trained immunity of myeloid cells and their progenitors in patients with non-medullary thyroid carcinoma, colon carcinoma and melanoma

Recruiting

• Conditions: colon carcinioma; thyroid carcinoma; 10014713

• Registration Number: NL-OMON53801
• Lead Sponsor: Interne Geneeskunde

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 90

Inclusion Criteria

-Subjects should be at least 18 years old and mentally competent

-Newly diagnosed patients with TC, CC or melanoma or with newly diagnosed
metastases and that are planned to receive conventional treatment by surgery

Exclusion Criteria

-Mentally incompetent
-Pregnant or breastfeeding
-Using medication interfering with the immune system
-Reduced platelets counts or other conditions associated with an increased risk
of bleeding
- Severe comorbidities; other active malignancies (except for basalcel
carcinoma)
- Surgery of the primary tumor in the previous 4 months.
-Serious psychiatric pathology
-A self-reported alcohol consumption of >21 units per week

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Transcriptional, epigenetic and functional signature of circulating monocytes<br /><br>and BM myeloid progenitors before and after in vitro exposure to trained<br /><br>immunity inducing agents.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>