Vitamin A for BPD Prevention

Not Applicable

• Conditions: The Relationship Between Oral Vitamin A Administration and the Incidence of BPD in Preterm Infants Born Before Week 29 of Pregnancy
• Interventions: Dietary Supplement: Oral Vitamin A

• Registration Number: NCT04563429
• Lead Sponsor: Sheba Medical Center

Brief Summary

Chronic bronchopulmonary dysplasia (BPD) is a very common complication in preterm infants born at a young gestational age, and is a serious disease that impairs respiratory long-term outcome and is associated with higher-frequency neurodevelopmental injury. Lowering the incidence of BPD may improve the health of the preterm babies and neurodevelopmental delay of preterm infants.Vitamin A deficiency may be one of the factors associated with the development of BPD in preterm infants. According to the literature, oral vitamin A administration can lower the incidence of BPD. In our study we plan to give 5000 units of retinol / dose / day, every day for 28 days.

Detailed Description

Not available

Study Timeline

• Status Verified: 2020-09
• Study First Submitted: 2020-09-22
• Study First Submitted QC: 2020-09-22
• Last Update Submitted: 2020-09-22
• Study First Posted: 2020-09-24
• Last Update Posted: 2020-09-24
• Study Start: 2020-10-01
• Primary Completion: 2022-10-01
• Study Completion: 2023-10-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Premature babies under 29 weeks, at any birth weight
• A preterm baby is less than 4 days to life

Exclusion Criteria

• Major congenital malformations
• Known chromosomal disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Treatment Group	Oral Vitamin A	-

Primary Outcome Measures

Name	Time	Method
Incidence of BPD at 28 days	28 days of life	Chronic pulmonary desease of prematue babies
Incidence of mortality at 28 days	28 days of life	Death before 28 days of life