Metabolic Effects of Snuff and Red Wine
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 14
- Locations
- 1
- Primary Endpoint
- level of metabolic rate
Study Overview
Brief Summary
About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured every hour for four hours on each occasion starting in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal.
Detailed Description
About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured measured before the meal and then every hour for a total of four hours on each occasion that starts in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal. Since there are four possible combinations of the wine and the snuff, all participants do the test on four occasions. Except for metabolic rate we will also analyze hormone responses regarding appetite or hunger.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Single (Participant)
Masking Description
We use non-alcoholic or alcohol containing wine and regular or nicotine free snuff
Eligibility Criteria
- Ages
- 18 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •No significant disease -
Exclusion Criteria
- •known illnesses, thyroid disease, need to take prednisolone, psychiatric disease,inability to understand Swedish
Arms & Interventions
red wine and snuff
regular red wine and moist snuff
Intervention: Wine with or without alcohol and snuff with or without nicotine (Other)
red wine and nicotine-free snuff
regular red wine and nicotine-free snuff
Intervention: Wine with or without alcohol and snuff with or without nicotine (Other)
non alcoholic red wine and regular moist snuff
non alcoholic red wine and regular moist snuff with nicotine
Intervention: Wine with or without alcohol and snuff with or without nicotine (Other)
non-alcoholic red wine and nicotine-free snuff
Non-alcoholic red wine and nicotine-free snuff
Intervention: Wine with or without alcohol and snuff with or without nicotine (Other)
Outcomes
Primary Outcomes
level of metabolic rate
Time Frame: 4 hours
Measurement of metabolic rate by registration of CO2 in breath and the oxygen uptake
Secondary Outcomes
- sense of appetite(4 hours)
Investigators
Fredrik H Nystrom
professor, MD
University Hospital, Linkoeping