Comparison of Cardiac Index and Cardiac Output Effect During Maintenance Hemodialysis Between Acetate-Free and Acetate-Based Online Hemodiafiltration
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 1
- 主要终点
- cardiac index
研究概览
简要总结
The purpose of this study is to detemine whether effect of Acetate-free solution on cardiac index and cardiac output measured by saline dilution techniques compares with Acetate-based solution in online-hemodiafiltration
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •End-stage renal disease patients with age over 20 years and stable clinical status
- •Dialytic age > 6 months
- •Maintenance hemodialysis with online-hemodiafiltration mode at King Chulalongkorn Memorial Hospital
- •Use arteriovenous fistula or arteriovenous graft as vascular access for hemodialysis
- •No vascular access recirculation
- •No liver impairment
- •No severe, intractable metabolic acidosis or alkalosis (HCO3 <15, >30)
- •No pre-existing severe, intractable hypocalcemia (Ca < 7.5) or clinical of hypocalcemia
排除标准
- •On hemodialysis via tunnel catheter
- •Vascular access recirculation
- •Liver dysfunction
- •Severe, intractable metabolic acidosis or alkalosis (HCO3 <15, >30)
- •Pre-existing severe, intractable hypocalcemia (Ca < 7.5) or clinical of hypocalcemia
- •Acute or recent myocardial ischemia or congestive heart failure (within 1 months)
- •Threatening arrhythmia (VT, VF, sustained SVT, AF with rapid ventricular response)
- •Patients affected by acute or chronic infections, malignant tumor
研究组 & 干预措施
Acetate-free solution first
Acetate-free solution first : hemodialysis 4 hours with Acetate-free solution (Acetate 0 mEq/L Citrate 2 mEq/L) at the first session after enrollment, and then switch to Acetate-based solution (Acetate 3 mEq/L Citrate 0 mEq/L) at the next 4-hr hemodialysis session
干预措施: Acetate-free dialysis solution (Biological)
Acetate-based solution first
Acetate-based solution first : hemodialysis 4 hours with Acetate-based solution (Acetate 3 mEq/L Citrate 0 mEq/L) at the first session after enrollment, and then switch to Acetate-free solution (Acetate 2 mEq/L Citrate 2 mEq/L) at the next 4-hr hemodialysis session
干预措施: Acetate-free dialysis solution (Biological)
结局指标
主要结局
cardiac index
时间窗: 6 months
cardiac index and cardiac output was measured by ultrasound dilution technique
Cardiac output
时间窗: 6 months
cardiac index and cardiac output was measured by ultrasound dilution technique
次要结局
- blood pressure(6 months)
- peripheral vascular resistance(6 moths)
- Patients' symptoms(6 months)
研究者
Khajohn Tiranathanagul
Doctor
Chulalongkorn University