Psychometric and neurological evaluation of mental representations of daily activities in dementia patients

• Conditions: F02.0; F06.7; F00; Alzheimer disease with late onset; Dementia in Pick disease; G30.1; Dementia in Alzheimer disease; Mild cognitive disorder

• Registration Number: DRKS00023340
• Lead Sponsor: Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) e.V., Greifswald

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-28
• Study Completion: 2024-02-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting stopped after recruiting started
• Sex: All
• Target Recruitment: 4

Inclusion Criteria

Requirements for participation: (1) at least 65 years of age, (2) sufficient visual, hearing and speech skills, (3) no test-relevant motor disorders, (4) no other confounding neurological diseases (can be excluded with with the help of the clinical data), (5) a declaration of consent signed by the test person and, if applicable, his guardian.

Exclusion Criteria

Exclusion criterion for participation: (1) Insufficient resilience based on physical or psychological well-being, (2) Unclear whether the person would like to participate in the study.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The projects´primary dependent variable are the mental representations of daily activities that are assessed by using the Script Generation Task.

Secondary Outcome Measures

Name	Time	Method
The projects´ secondary dependent variable are the functional ability to cope with daily life independently (Katz index of independence in carrying out the activities of daily living, Lawton Instrumental Activities of Daily Living Scale), individual cognitive domains (Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test battery, Cambridge Semantic Memory Test Battery, Digit Span Test), the emotional content of mental representations (Script Generation Task), affective symptoms ((German version of the Positive and Negative Affect Schedule, Ruminative Response Scale , Big Five Inventory, Penn State Worry Questionnaire) and Brain Structural Differences (MRI).