Discovery of serum biomarkers for the diagnosis of sport-related concussion in children.

Not Applicable

• Conditions: Sports related concussion; Minor traumatic brain injury; Neurological - Other neurological disorders; Injuries and Accidents - Other injuries and accidents

• Registration Number: ACTRN12620000022965
• Lead Sponsor: SW

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-01-15
• Last Update Posted: 3 February 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Males and females between the ages of 10-18 years participating in high-contact (impact) sports (patients) and age and sex matched young people not involved in high-contact (impact) sports (controls).

Exclusion Criteria

Potential participants with acute exacerbation of allergic inflammation including but not restricted to asthma, eczema, food allergy or anaphylaxis, individuals with recent head injury (<6 months), existing neurological or non-neurological chronic diseases, recent major surgery or those who suffered multiple injuries in the current incident will be excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum tryptase levels over time following a concussion.[1-3 days (primary timepoint) following a concussion and then repeated at 7, 14 and 28 days to assess how long levels remain elevated.]

Secondary Outcome Measures

Name	Time	Method
Cognitive function as assessed by ImPACT.[1-3 days following a concussion and then repeated at 7, 14 and 28 days.];Concsussion symptoms as assessed using the Sports Concussion Assessment Tool.[1-3 days following a concussion and then repeated at 7, 14 and 28 days.];Exercise Tolerance as assessed using a treadmill Bruce protocol[1-3 days following a concussion and then repeated at 7, 14 and 28 days.]