REtinaL Imaging & Ambulatory BLood PrEssure: Validating Ultra-widefield Retinal Imaging Derived Biomarkers Against Ambulatory Blood Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 591
- 试验地点
- 1
- 主要终点
- Does retinal arteriovenous ratio correlate to systolic blood pressure
研究概览
简要总结
High blood pressure is a common condition which generally does not have any symptoms. Its estimated that around one third of people with high blood pressure do not know they have it. The back of the eye called the retina is one of the few places in the human body allowing easy observation of blood vessels. This study aims to see if simple non-invasive imaging of the blood vessels of the retina will highlight people with high blood pressure.
详细描述
This will be a prospective, single centre study recruiting patients who are attending the ambulatory blood pressure clinic at the Western General Hospital. Suitable patients will be approached, and if they consent will have pictures of the back of each of their eyes taken. These pictures will then be reviewed, with certain measurements taken of the small blood vessels which can been seen at the back of the eye. These measurements will then be compared to the participants blood pressure readings to see if they might accurately correlate to blood pressure.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Attending ambulatory blood pressure clinic
- •Able to undertake ambulatory BP measurement
- •Able to undertake single clinic-based BP measurement
- •Able to undergo UWF retinal imaging with a SLO
- •Aged 18 to 90
- •Able to give informed consent
排除标准
- •People with known history of retinal surgery
- •People under the age of 18 years.
- •People that cannot: manoeuvre themselves to the SLO unaided, sit upright in a chair or wheelchair or position themselves comfortably for imaging.
- •People with epilepsy
结局指标
主要结局
Does retinal arteriovenous ratio correlate to systolic blood pressure
时间窗: 1 day
Retinal arteriovenous ratio (as measured by ultra-wide field imaging) will be correlated to mean daytime systolic blood pressure (as measured by 24-hour ambulatory blood pressure monitoring)
次要结局
- Does retinal arteriovenous ratio correlate to clinic systolic blood pressure(1 day)