Studying effect of propofol and ketamine as induction agents in electro convulsive therapy in patients with depression.
Phase 4
- Conditions
- Health Condition 1: F332- Major depressive disorder, recurrent severe without psychotic features
- Registration Number
- CTRI/2024/03/064547
- Lead Sponsor
- Kapuri Manasa
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients of both sexes between age 18-65 years.
Patients with severe depressive disorder requiring electro convulsive therapy.
Patients with American Society of Anaesthesiology (ASA) physical status l & ll .
Exclusion Criteria
Pregnant females and lactating mothers.
Patients on chronic opiate use such as tramadol.
Known allergies to study drugs.
Patients with hypertension, IHD and other heart diseases.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method A) <br/ ><br>1)Mean blood pressure <br/ ><br>2)Heart rate <br/ ><br>3)Oxygen Saturation <br/ ><br>B) <br/ ><br>1)Spontaneous eye opening <br/ ><br>2)Obeying verbal commands <br/ ><br>C) <br/ ><br>MADRS(Montgomery Asberg Depression Rating Scale)Timepoint: A) <br/ ><br>2min before premedication <br/ ><br>2min after induction <br/ ><br>5min, 10min, 15min, 20min after giving shock and onset of seizures <br/ ><br>B) <br/ ><br>0min, 5min,10min, 15min post ect <br/ ><br>C) <br/ ><br>1st & 2nd week post ect
- Secondary Outcome Measures
Name Time Method Incidence & severity of post ect agitationTimepoint: 15 min post ect;Incidence & severity of post ect myalgiaTimepoint: 6hrs & 12hrs post ect;Seizure durationTimepoint: 10 min after induction