Leucine and Beta-hydroxy-beta-methylbutyrate (HMB) as Anabolic Nutrients After 36 Hours of Fasting
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Protein metabolism after 36 hours fasting receiving different nutritional supplements.
研究概览
简要总结
The purpose of this study is to investigate metabolic effects of 3 different nutritional compounds.
Fasting (36 hours) creates a catabolic state that is comparable with the catabolic state seen in acute illness.
This study is a randomized, placebo cross-over study investigating 8 healthy men on 4 separated days (at least 3 weeks between trials).
- High leucine content drink
- Low leucine content drink
- Low leucine content drink + HMB
- Carbohydrate (isocaloric)
The investigators hypothesize that these nutritional supplements may counteract catabolic processes in different ways and degrees.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •male gender
- •20<BMI<30
- •Age > 20 years old
- •Written consent before starting the study
排除标准
- •Allergy for soya products ore egg
- •Infection
- •Immune defects
- •Heart disease
- •Dysregulated hypertension
- •Participating in other trials using radioactive tracers or x-rays the last year.
结局指标
主要结局
Protein metabolism after 36 hours fasting receiving different nutritional supplements.
时间窗: 3 control period followed by 4 hours of nutritional drink intake
Protein metabolism is measured with amino acid tracer techniques comparing marked amino acids from blood samples. Muscle and fat biopsies are obtained for signaling analysis. Indirect calorimetry measurements are used to compare metabolism in the control period and during the intervention.
次要结局
未报告次要终点
研究者
Nikolaj Fibiger Rittig
MD (medical graduate) and Ph.d.-student
University of Aarhus