Effects of Dietary Manipulation on Metabolism in Healthy Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Metabolic Regulation
- Sponsor
- Beth Israel Deaconess Medical Center
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Changes in circulating plasma levels of key metabolic regulators
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
This study will examine the potential changes in the blood levels of a recently discovered metabolic regulator in response to changes in diet in healthy adults. Our hypothesis is that in healthy adults key regulatory factors involved in lipid oxidation will respond to changes in diet, particularly fasting and diet-induced ketosis.
Detailed Description
There is scant data regarding the metabolic events that occur in humans during ketosis which may be brought about by fasting or ingestion of diets low in carbohydrate. We aim to employ both fasting and dietary manipulation in order to bring about a ketotic state in healthy human adults. During the study blood levels of key metabolic regulators will be monitored 1) during a 16 hour fast followed by re-feeding and 2) during dietary induction of ketosis followed by re-feeding with a standard meal.
Investigators
Jody Dushay
Principal Investigator
Beth Israel Deaconess Medical Center
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •Type 1 or type 2 diabetes mellitus diagnosed according to American Diabetes Association criteria
- •Coronary heart disease (history of myocardial infarction, unstable angina pectoris, or congestive heart failure)
- •Uncontrolled hypertension (BP \> 150/90 mmHg on or off antihypertensive medication)
- •Dyslipidemia
- •Tobacco, marijuana or intravenous drug use
- •Shift workers (night shift or alternating day/night shifts)
- •Recent weight loss (\> 3 kg within 6 months of the screening visit)
- •Gastroparesis
- •Inflammatory bowel disease
- •Malignancy treated with chemotherapy within the past 3 years
Outcomes
Primary Outcomes
Changes in circulating plasma levels of key metabolic regulators
Time Frame: 1 week
Secondary Outcomes
- A secondary outcome is change in energy expenditure with diet-induced ketosis.(1 week)