Impacts of Metabolic Variation on the Activity of Neuroendocrine Reproductive Axis in Healthy Volunteers

Centre Hospitalier Universitaire Vaudois1 site in 1 country9 target enrollmentJanuary 2010

ConditionsNeuroendocrine Reproductive Status

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Neuroendocrine Reproductive Status
Sponsor: Centre Hospitalier Universitaire Vaudois
Enrollment: 9
Locations: 1
Primary Endpoint: Luteinizing hormone (LH) pulsatility
Status: Completed
Last Updated: 14 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

This study will evaluate the potential effects of a changing metabolic environment on GnRH hypothalamic neurons, by performing studies of LH pulsatility (basal and during clamp studies) in different groups of male subjects fed isocaloric and hypercaloric diets. The participation of other gastro-intestinal tract hormones to these regulations will be systematically evaluated.

Registry

clinicaltrials.gov

Start Date

January 2010

End Date

October 2010

Last Updated

14 years ago

Study Type

Interventional

Study Design

Crossover

Sex

Male

Investigators

Sponsor

Centre Hospitalier Universitaire Vaudois

Eligibility Criteria

Inclusion Criteria

•age between 18 and 25 years old
•no known pathology
•normal physical exam
•BMI between 20 and 25 kg/m2

Exclusion Criteria

•history of endocrine disease
•no known infertility (no conception after 12 months of regular unprotected intercourse)
•abnormal results on the initial blood tests (CBC, fasting glucose and insulin, HbA1C, TSH, free T4, LH, FSH, inhibin B and total testosterone)