Effect of Metabolic Variations Upon the Activity of the Neuroendocrine Reproductive Axis in Normal Female Volunteers

Centre Hospitalier Universitaire Vaudois1 个研究点分布在 1 个国家目标入组 9 人2014年1月

适应症Female Reproductive System Disorder

概览

阶段: 不适用
干预措施: 未指定
疾病 / 适应症: Female Reproductive System Disorder
发起方: Centre Hospitalier Universitaire Vaudois
入组人数: 9
试验地点: 1
主要终点: Luteinizing hormone secretion
状态: 已完成
最后更新: 10年前

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概览

简要总结

Undernutrition has a known and well recognized negative impact on reproductive hormones, and ultimately fertility. In contrast, much less is known regarding the potential effects of overnutrition on the same hormones. Epidemiological data suggest that overnutrition might have a deleterious impact as well on the fertile potential of affected women, but very little is known about the mechanisms implicated. Such knowledge may be of importance, given the increasing prevalence of overweight and obesity worldwide.

详细描述

In the present study, the investigators will perform a very detailed study of the minute to minute regulation of hormones of the neuroendocrine reproductive axis in normal young female volunteers. These studies will initially be performed at base line during isocaloric diet, where the stimulation of LH secretion by exogenous insulin will be tested during hyperinsulinemic eugylcemic clamp studies. The same studies will then be repeated after a period of one month of controlled hypercaloric diet, where volunteers will receive an excess of approximately 30% KCal compared to their calculated daily energy expenditure. it is anticipated that such hypercaloric nutrition will induce a significant decrease in normal insulin sensitivity of these volunteers. Thus, the effect of changing whole body insulin sensitivity on the fine regulation of neuroendocrine reproductive hormones will be evaluated.

注册库

clinicaltrials.gov

开始日期

2014年1月

结束日期

2015年6月

最后更新

10年前

研究类型

Interventional

研究设计

Crossover