Computerized Cognitive Training in Epilepsy

Not Applicable

Withdrawn

• Conditions: Epilepsy
• Interventions: Behavioral: Monster Garden Exercise; Behavioral: Spatial Match Exercise; Behavioral: Temporal Sequence Reconstruction Exercise; Behavioral: Memory Match Exercise; Behavioral: Token Task Exercise; Behavioral: Memory Matrix Exercise; Behavioral: Familiar Faces Exercises; Behavioral: Story Recall Exercise; Behavioral: Lost in Migration Exercise; Behavioral: Sample-Match (Within Modality) Exercise; Behavioral: Pair-Match (Across-Modality) Exercise; Behavioral: Playing Koi Exercise; Behavioral: Triad-FiguresExercise

• Registration Number: NCT02726191
• Lead Sponsor: NYU Langone Health

Brief Summary

The purpose of this randomized uncontrolled single-site trial is to evaluate the efficacy of two novel computerized cognitive enhancing software packages for improving cognitive and behavioral outcomes in patients with epilepsy.

Detailed Description

The proposed investigation will be the first to pit two software packages against each other to evaluate the relative efficacy and feasibility of their use among patients with epilepsy. Pharmacotherapy fails to control seizures in approximately 30% of patients. Use of non-pharmacologic interventions, such as cognitive rehabilitation, has shown some benefit for improving cognitive functions and reducing mood symptoms. Each of the computer exercises employ a set of stimuli that are generalizable and mimic real-world experiences.

Study Timeline

• Study First Submitted: 2016-03-22
• Study First Submitted QC: 2016-03-28
• Study First Posted: 2016-04-01
• Study Start: 2017-01
• Status Verified: 2017-07
• Primary Completion: 2017-07
• Last Update Submitted: 2017-07-13
• Last Update Posted: 2017-07-18
• Study Completion: 2018-04

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
• Must own a computer or have access to the internet.

Read More

Exclusion Criteria

• Full Scale IQ < 80, as assessed by the WASI-II.
• History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Parkinson's disease, multiple sclerosis, dementia, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
• History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
• Visual or auditory impairment, which precludes participation in part, or all of the testing.
• English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for >10 years.

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lumosity	Monster Garden Exercise	-
Posit Science	Triad-FiguresExercise	-
Lumosity	Lost in Migration Exercise	-
Posit Science	Token Task Exercise	-
Posit Science	Temporal Sequence Reconstruction Exercise	-
Posit Science	Sample-Match (Within Modality) Exercise	-
Lumosity	Familiar Faces Exercises	-
Posit Science	Story Recall Exercise	-
Posit Science	Pair-Match (Across-Modality) Exercise	-
Lumosity	Memory Matrix Exercise	-
Posit Science	Spatial Match Exercise	-
Lumosity	Memory Match Exercise	-
Lumosity	Playing Koi Exercise	-

Primary Outcome Measures

Name	Time	Method
Total Index Score from the Repeatable Battery for the Assessment of Neurocognitive Status (RBANS)	8 Weeks

Secondary Outcome Measures

Name	Time	Method
Perceived cognitive abilities on an index of subjective cognitive abilities (Cognitive Self-Report Questionnaire; CSRQ-25)	8 Weeks
The Everyday Cognition Scale (ECog)	8 Weeks
Measure of mood (Geriatric Depression Scale)	8 Weeks

Trial Locations

Locations (1)

New York University School of Medicine; 🇺🇸 New York, New York, United States