Computerized Cognitive Training in Epilepsy
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- Total Index Score from the Repeatable Battery for the Assessment of Neurocognitive Status (RBANS)
研究概览
简要总结
The purpose of this randomized uncontrolled single-site trial is to evaluate the efficacy of two novel computerized cognitive enhancing software packages for improving cognitive and behavioral outcomes in patients with epilepsy.
详细描述
The proposed investigation will be the first to pit two software packages against each other to evaluate the relative efficacy and feasibility of their use among patients with epilepsy. Pharmacotherapy fails to control seizures in approximately 30% of patients. Use of non-pharmacologic interventions, such as cognitive rehabilitation, has shown some benefit for improving cognitive functions and reducing mood symptoms. Each of the computer exercises employ a set of stimuli that are generalizable and mimic real-world experiences.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Documented diagnosis of epilepsy based on medical records. The records will be reviewed by the PI and the approved study personnel to confirm that a diagnosis of epilepsy has been made.
- •Must own a computer or have access to the internet.
排除标准
- •Full Scale IQ < 80, as assessed by the WASI-II.
- •History of chronic progressive neurologic or neurodegenerative illnesses (e.g., Parkinson's disease, multiple sclerosis, dementia, primary or metastatic malignancy). Patients with headache or migraine are not excluded.
- •History of Axis I psychiatric illness with psychotic features. (e.g., schizophrenia). Patients with depression or anxiety (treated or untreated) without psychotic features are not excluded.
- •Visual or auditory impairment, which precludes participation in part, or all of the testing.
- •English as a first language will not be required, but participants must have either received some of their schooling in English or used English in their work for >10 years.
研究组 & 干预措施
Posit Science
干预措施: Story Recall Exercise (Behavioral)
Posit Science
干预措施: Sample-Match (Within Modality) Exercise (Behavioral)
Posit Science
干预措施: Pair-Match (Across-Modality) Exercise (Behavioral)
Posit Science
干预措施: Triad-FiguresExercise (Behavioral)
Posit Science
干预措施: Spatial Match Exercise (Behavioral)
Posit Science
干预措施: Temporal Sequence Reconstruction Exercise (Behavioral)
Posit Science
干预措施: Token Task Exercise (Behavioral)
Lumosity
干预措施: Memory Matrix Exercise (Behavioral)
Lumosity
干预措施: Familiar Faces Exercises (Behavioral)
Lumosity
干预措施: Lost in Migration Exercise (Behavioral)
Lumosity
干预措施: Playing Koi Exercise (Behavioral)
Lumosity
干预措施: Monster Garden Exercise (Behavioral)
Lumosity
干预措施: Memory Match Exercise (Behavioral)
结局指标
主要结局
Total Index Score from the Repeatable Battery for the Assessment of Neurocognitive Status (RBANS)
时间窗: 8 Weeks
次要结局
- Measure of mood (Geriatric Depression Scale)(8 Weeks)
- Perceived cognitive abilities on an index of subjective cognitive abilities (Cognitive Self-Report Questionnaire; CSRQ-25)(8 Weeks)
- The Everyday Cognition Scale (ECog)(8 Weeks)